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Fig. 2 | BMC Genomics

Fig. 2

From: Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver

Fig. 2

The immature F. hepatica parasites display a different profile of gene expression compared with F. gigantica. a Venn diagram representing the number of significantly enriched GO terms shared between the F. hepatica immature flukes at 21 days post infection (F. hepatica_21dpi) and the F. gigantica immature flukes at 42- and 70-days post infection (F. gigantica_42dpi; F. gigantica_70dpi). The numbers in brackets depict the total number of enriched GO terms per dataset. Description of the GO terms is presented in Additional file 4. b Graphical representation of the top 150 abundantly transcribed genes from F. hepatica immature flukes at 21 days post infection (F. hepatica_21dpi) and the F. gigantica immature flukes at 42- and 70-days post infection (F. gigantica_42dpi; F. gigantica_70dpi). Data is represented as the percentage abundance relative to total gene transcription for each dataset, with genes grouped by gene family where possible. c-f Schematic representation of the gene ontology (GO) enrichment analysis using REVIGO based on molecular function and biological processes highlighting the enriched GO terms that play a role as the parasite grows and develops. c Molecular function GO terms within the F. hepatica immature transcriptome. d Biological process GO terms within the F. hepatica immature fluke transcriptome. e Molecular function GO terms within the F. gigantica immature fluke transcriptomes. f Biological process GO terms within the F. gigantica immature transcriptomes. The bubble colour indicates the log value of the FDR adjusted p value and the circle size (plot size) represents the frequency of the GO term within the gene ontology annotation database (GOA; more general terms represented by larger plot size)

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