Fig. 6

Host and parasite genes that play a critical role for tolerating the oxidative stress induced by F. hepatica infection. a Graphical representation of the fold change in transcription of genes associated with fibrosis and inflammation, and proline metabolism within liver tissue from non-infected and F. hepatica-infected mice (b) Graphical representation of the fold change in transcription of genes associated with oxidative stress within liver tissue from non-infected and F. hepatica-infected mice. Data for a & b is extrapolated from the microarray data generated by Rojas-Caraballo and colleagues, [11]. Details of the gene abbreviations are provided in Additional file 8. c Graphical representation of the transcription of key antioxidant related genes within the F. hepatica immature fluke transcriptome, based on FPKM values. d Graphical representation of the protein abundance of key antioxidant related proteins within the F. hepatica immature fluke somatic proteome and secretome. Abbreviations for panels B and C: PRX, peroxiredoxin; GST, glutathione S transferases; GPx, glutathione peroxidase; MGST, microsomal glutathione S transferases; TRX, thioredoxin; SOD, superoxide dismutase; GSS, glutathione synthetase, GRX, glutaredoxin