Fig. 2
Correlation between the change in methylation of CpG sites in promoter and TSS regions in RBC data with the change in methylation of those in liver data that showed a significant change in methylation for Δ1,2 (a) and Δ2,3 (b). Methylation changes are visualized as normalized changes (z-scores). Sites that change significantly in methylation in both tissues (tissue-general change) in promoter and TSS regions are shown in blue (n = 38 for Δ1,2 and 77 for Δ2,3) and green (n = 4 for Δ1,2 and 7 for Δ2,3), respectively. Sites that change significantly in methylation in one of the tissues (tissue-specific change), independent of gene region, are shown in grey (n = 287 for Δ1,2 and 606 for Δ2,3). We applied transparency because of the high number of overlapping data points. Line is the regression line