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Fig. 3 | BMC Genomics

Fig. 3

From: Correction for both common and rare cell types in blood is important to identify genes that correlate with age

Fig. 3

EM aging-related genes are not related to specific blood cell populations. a) Cell-type clustering of single cell RNA-seq (scRNA-seq) data. b) The mean expression value of aging-related genes from the initial model (IM, left) and the extended model (EM, right) is plotted in the single cells. c) The age distribution of the scRNA-seq donors. In d), the distributions of the mean gene expression for IM- and EM-related genes across every cell in the t-SNE plots from b) are reported. e) The distributions of the coefficient of variation are presented for both the IM and EM. Statistical significance for d) and e) was assessed with a Wilcoxon test. The level of statistical significance was set at P ≤ 0.05. For details regarding cell population-specific regions, refer to [20]

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