Fig. 1
From: De novo ZIC2 frameshift variant associated with frontonasal dysplasia in a Limousin calf
Macroscopic pictures of the skull of the affected calf (a, b) showing severe deformations and absence of facial structures. The nose and the maxilla were not developed and the mandibles were curved upwards. Eyes and orbital cavities were absent. The tongue was protruded. Centrally on the skull a defect was present (asterisk), insert showing a higher magnification of the defect after removal of the skin