Fig. 3
From: Identifying critical state of complex diseases by single-sample Kullback–Leibler divergence
The application of sKLD in acute lung injury. a As shown in the red curve, the peak for the sKLD appears at 8 h, which can be used as an early signal of acute lung injury deterioration. The result is consistent with the experimental observation. To illustrate the significance of the result, six yellow curves are derived based on six sets of datasets generated from a leave-one-out scheme, which consistently indicate the tipping point at 8 h. b The figure shows the dynamical changes in the distribution of signaling genes for the case data and control data, respectively. c From the dynamical evolution of the network composed by the top 5% most significant genes in terms of the cumulative area of the case sample, it is seen that the an obvious change in the network structure appear at 8 h