Table 3 The genes with high frequency in 59 “sKLD-signaling genes” groups in the critical stage (stage IIB) for LUAD
From: Identifying critical state of complex diseases by single-sample Kullback–Leibler divergence
Gene | Frequency | Location | Family* | Relation with cancer progression |
|---|---|---|---|---|
PYCR1 | 54 | Cytoplasm | enzyme | PYCR1 may be a novel therapeutic target for inhibiting cell proliferation in lung cancer [48]. |
ETV4 | 50 | Nucleus | transcription regulator | ETV4 promotes proliferation and invasion of lung adenocarcinoma by transcriptionally upregulating MSI2 [49]. |
PITX2 | 50 | Nucleus | transcription regulator | Knockdown of PITX2 inhibits cell proliferation, migration and invasion of LUAD [50]. |
MDK | 49 | Extracellular Space | growth factor | MDK plays an important role in non-small cell lung cancer progression and prognosis and may act as a convincing prognostic indicator for non-small cell lung cancer patients [51]. |
PPAT | 49 | Cytoplasm | enzyme | Blocking glutamine-mediated induction of PPAT inhibits cell proliferation and invasion in LUAD [52]. |
TOP2A | 49 | Nucleus | enzyme | TOP2A is an ideal candidate for miR-144-3p targets in non-small cell lung cancer and MiR-144-3p expression is significantly correlated with stage, lymph node metastasis and vascular invasion [53]. |
HOXC13 | 48 | Nucleus | transcription regulator | HOXC13 promotes proliferation of lung adenocarcinoma via modulation of CCND1 and CCNE1 [54]. |
SRPK1 | 48 | Nucleus | kinase | Up-regulation of SRPK1 in non-small cell lung cancer can promote the growth and migration of cancer cells [55]. |