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Fig. 4 | BMC Genomics

Fig. 4

From: Identification of functional regulatory elements in the human genome using pooled CRISPR screens

Fig. 4

p53-bound regulatory elements influence cellular response to DNA damage. a Comparison of log2 fold changes (relative to pDNA) for all sgRNAs in gene-targeting CRISPR library between replicates. b Log2 fold changes (relative to pDNA) in CRISPR screen for sgRNAs targeting selected subset of genes. FDR values were calculated using the Benjamini-Hochberg method. c Visualization of enrichment/depletion for sgRNAs targeting a selected subset of genes (red) compared to all sgRNAs in CRISPR library (black). d Comparison of log2 fold changes (relative to pDNA) for all sgRNAs in peak-targeting CRISPR library between replicates. e Volcano plot comparing significance of sgRNA enrichment/depletion and log2 fold change (relative to pDNA) for all sgRNAs in CRISPR library. f Visualization of enrichment/depletion for sgRNAs targeting a selected subset of peaks (red) compared to all sgRNAs in CRISPR library (black). g Comparison of log2 fold change (relative to pDNA) and distance from nearest annotated TSS for all sgRNAs in CRISPR library

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