Fig. 4

Long range effects of a large 8p23 inversion on chromatin conformation. A correlation heatmap shows chromatin interactions that are gained (red) and lost (blue) on the inversion haplotype relative to the reference (Panel a). The gray region corresponds to missing values that could not be normalized. The inversion region is depicted by the black triangle. Hi-C matrices for samples that were homozygous for the absence of an inversion and homozygous for the inversion at 8p23.1 were averaged separately and annotated (Panel b). The TAD structure is preserved in a mirrored fashion along with their associated genes. Chromatin interactions for the inversion were mirrored to aid visual comparison with the reference