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Fig. 4 | BMC Genomics

Fig. 4

From: Transcriptome analyses of liver in newly-hatched chicks during the metabolic perturbation of fasting and re-feeding reveals THRSPA as the key lipogenic transcription factor

Fig. 4

A gene interaction network (Panel a) of lipogenic (green symbols) and lipolytic (red symbols) AR-DEGS found in the D1FED24h vs. D1FAST24h contrast. This gene network was functionally annotated by IPA as “Lipid Metabolism/Molecular Transport”. These genes are differentially regulated by two transcription factors [catenin beta 1 (CTNNB1) and activating transcription factor 4 (ATF4)]. Ingenuity® Upstream Regulator Analysis identified additional direct targets for each transcription factor (Panel b) and predicts that CTNNB1 should be inhibited due to down-regulation of its eight direct target genes (EGFR, EPCAM, EPHB2, IGFBP2, IRF8, LY6E, SESN1 and CYB5A), although the expression of CTNNB1 and seven direct target genes were up-regulated (i.e., higher in D1FED24h). Ingenuity correctly predicted activation of ATF4 and up-regulation of four direct target genes including CTNNB1 and another transcription factor, Jun proto-oncogene, AP-1 transcription factor subunit (JUN)

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BMC Genomics

ISSN: 1471-2164

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