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Fig. 8 | BMC Genomics

Fig. 8

From: Transcriptome analyses of liver in newly-hatched chicks during the metabolic perturbation of fasting and re-feeding reveals THRSPA as the key lipogenic transcription factor

Fig. 8

A gene interaction network was identified in the D2FAST48h vs. D3RERFED24h contrast and functionally annotated by IPA as related to “Nutritional Disease” (Panel a). This gene network was centered on the interaction of the glucocorticoid receptor (NR3C1) and 16 direct target genes, including several components of the innate immune response/ inflammation (IL15, IL1RAP, TLR5 and HERPUD1) and regulators of lipolysis (SERTAD2 and CIDEA); all of which were highly expressed in liver of D2FAST48h chicks. Panel b shows another gene network related to “Lipid Metabolism” that involves the transcription factor forkhead 1 (FOX01) and its 16 direct targets that interact, via ALDOB, with three ATPases and glutathione transferases (GSTA2, MGST3 and HPGDS). The majority of the genes in this network are expressed higher in liver of D3REFED24h chicks, except FOX01, GRHPR, SLC25A20, IDO2, ALDOB and SLC25A25, which are up-regulated by the D2FAST48h treatment

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