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Table 3 IPA summary of liver transcriptomes in hatchling chicks–D2FAST48h vs. D2REFED4h contrast

From: Transcriptome analyses of liver in newly-hatched chicks during the metabolic perturbation of fasting and re-feeding reveals THRSPA as the key lipogenic transcription factor

Top Canonical Pathwaysp-valueOverlapRatio
Super-pathway of Cholesterol Biosynthesis4.68E-0935.7%10/28 Cholesterol
Biosynthesis I-III3.23E-0853.8%7/13
Protein Ubiquitination Pathway9.27E-079.4%24/255
Tryptophan Degradation III5.12E-0628.0%7/25
Zymosterol Biosynthesis1.01E-0566.7%4/6
Top Upstream Regulatorsp-value of overlap# Target genes
HNF4A1.64E-16126
PPARA3.12E-1546
NFE2L22.26E-1344
TP533.37E-1392
E2F12.26E-1144
Top Molecular and Cellular Functionsp-value# Genes
Cell Death and Survival7.95E-03 - 5.11E-10206
Lipid Metabolism7.07E-03 - 6.42E-09118
Small Molecule Biochemistry7.12E-03 - 6.42E-09160
Vitamin and Mineral Metabolism7.07E-03 - 4.29E-0839
Cellular Growth and Proliferation8.01E-03 - 7.35E-08217
Physiological System Development and Functionp-value# Genes
Reproductive System Development and Function4.46E-05 - 4.46E-058
Connective Tissue Development and Function7.76E-03 - 6.39E-0589
Embryonic Development5.24E-03 - 1.23E-0429
Cardiovascular System Development and Function5.24E-03 - 1.49E-0410
Tissue Morphology6.24E-03 - 1.99E-0463
Top Up-regulated genesFAST48h/REFED4hTop Down-regulated genesFAST48h/REFED4h
CYP4A222.53THRSPA−4.89
UPP22.49HKDC1−4.17
IGFBP21.79CYP51A1−3.60
NDRG11.77MSMO1−3.44
TDO21.68PLIN2−3.37
VSNL11.68ME1−2.78
HAL1.56UGP2−2.72
TDH1.53AACS−2.68
CEPT11.51ACSBG2−2.50
SLC16A51.46INSIG1−2.43
  1. Ingenuity Pathway Analysis (IPA) was used for functional analysis of 641 “Analysis Ready” (AR)-DEGs found in the D2FAST48h vs.D2REFED4h contrast. The top 10 up-regulated and down-regulated AR-DEGs are presented along with their respective log2 ratio of treatment conditions