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Table 4 IPA summary of liver transcriptomes in hatcling chicks–D2FAST48h vs. D3REFED24h contrast

From: Transcriptome analyses of liver in newly-hatched chicks during the metabolic perturbation of fasting and re-feeding reveals THRSPA as the key lipogenic transcription factor

Top Canonical Pathwaysp-valueOverlapRatio
Tryptophan Degradation III4.58E-1256.0%14/25
NRF2-mediated Oxidative Stress Response4.30E-0917.1%33/193
Super-pathway of Cholesterol Biosynthesis8.44E-0942.9%12/28
Protein Ubiquitination Pathway1.42E-0814.7%39/265
Fatty Acid -oxidation I5.11E-0837.5%12/32
Top Upstream Regulatorsp-value of overlap# Target genes
HNF4A5.44E-22224
E2F16.07E-1981
PPARA9.50E-1977
NFE2L24.82E-1668
E2F47.81E-1648
Top Molecular and Cellular Functionsp-value# Genes
Cell Death and Survival3.73E-04 - 9.50E-20434
Cell Cycle3.58E-04 - 7.37E-18270
Cellular Assembly and Organization2.92E-04 - 6.25E-17103
DNA Replication, Recombination, and Repair3.58E-04 - 6.25E-17176
Amino Acid Metabolism2.69E-04 - 2.67E-1238
Physiological System Development and Functionp-value# Genes
Organismal Survival6.21E-09 - 2.57E-09278
Digestive System Development and Function1.35E-04 - 1.47E-0782
Hepatic System Development and Function4.62E-05 - 1.47E-0753
Organ Morphology3.43E-05 - 1.47E-0752
Organismal Development4.62E-05 - 1.47E-0765
Up-regulated genesFAST48h-REFED24hDown-regulated genesFAST48h-REFED24h
IGFBP23.19THRSPA−5.99
ADSL3.19ME1−4.84
LDHB2.90SCD−4.72
MBL22.85LGALS2−3.65
ALB2.71CYP51A1−3.30
CYP4A222.66PLIN2−3.26
UPP22.61FADS2−3.24
BHMT2.56CDK1−3.06
CYP3A72.40RRM2−3.03
NEFH2.39CDCA3−2.93
  1. Ingenuity Pathway Analysis (IPA) was used for functional analysis of 1198 “Analysis Ready” (AR)-DEGs from the D2FAST48h vs. D3REFED24h contrast. The top 10 up-regulated and down-regulated AR-DEGs are presented along with their respective log2 ratio of treatment conditions