Table 4 IPA summary of liver transcriptomes in hatcling chicks–D2FAST48h vs. D3REFED24h contrast
Top Canonical Pathways | p-value | Overlap | Ratio |
|---|---|---|---|
Tryptophan Degradation III | 4.58E-12 | 56.0% | 14/25 |
NRF2-mediated Oxidative Stress Response | 4.30E-09 | 17.1% | 33/193 |
Super-pathway of Cholesterol Biosynthesis | 8.44E-09 | 42.9% | 12/28 |
Protein Ubiquitination Pathway | 1.42E-08 | 14.7% | 39/265 |
Fatty Acid -oxidation I | 5.11E-08 | 37.5% | 12/32 |
Top Upstream Regulators | p-value of overlap | # Target genes | |
HNF4A | 5.44E-22 | 224 | |
E2F1 | 6.07E-19 | 81 | |
PPARA | 9.50E-19 | 77 | |
NFE2L2 | 4.82E-16 | 68 | |
E2F4 | 7.81E-16 | 48 | |
Top Molecular and Cellular Functions | p-value | # Genes | |
Cell Death and Survival | 3.73E-04 - 9.50E-20 | 434 | |
Cell Cycle | 3.58E-04 - 7.37E-18 | 270 | |
Cellular Assembly and Organization | 2.92E-04 - 6.25E-17 | 103 | |
DNA Replication, Recombination, and Repair | 3.58E-04 - 6.25E-17 | 176 | |
Amino Acid Metabolism | 2.69E-04 - 2.67E-12 | 38 | |
Physiological System Development and Function | p-value | # Genes | |
Organismal Survival | 6.21E-09 - 2.57E-09 | 278 | |
Digestive System Development and Function | 1.35E-04 - 1.47E-07 | 82 | |
Hepatic System Development and Function | 4.62E-05 - 1.47E-07 | 53 | |
Organ Morphology | 3.43E-05 - 1.47E-07 | 52 | |
Organismal Development | 4.62E-05 - 1.47E-07 | 65 | |
Up-regulated genes | FAST48h-REFED24h | Down-regulated genes | FAST48h-REFED24h |
IGFBP2 | 3.19 | THRSPA | −5.99 |
ADSL | 3.19 | ME1 | −4.84 |
LDHB | 2.90 | SCD | −4.72 |
MBL2 | 2.85 | LGALS2 | −3.65 |
ALB | 2.71 | CYP51A1 | −3.30 |
CYP4A22 | 2.66 | PLIN2 | −3.26 |
UPP2 | 2.61 | FADS2 | −3.24 |
BHMT | 2.56 | CDK1 | −3.06 |
CYP3A7 | 2.40 | RRM2 | −3.03 |
NEFH | 2.39 | CDCA3 | −2.93 |