Table 4 List of genes involved in insulin signalling pathway of Pde6c mutant zebrafish (p-value = 5.64e-03; FDR = 9.83e-02)
Ref mRNA | Gene Symbol | Gene Name | logFC | p-value |
|---|---|---|---|---|
NM_001004527 | ppp1cb | protein phosphatase 1, catalytic subunit, beta isozyme | −13.3391067 | 5.63E-09 |
NM_131855 | prkci | protein kinase C, iota | −11.4865862 | 4.49E-05 |
NM_213075 | flot2a | flotillin 2a | −11.94140373 | 7.05E-06 |
NM_001142672 | insra | insulin receptor a | −4.775105577 | 2.21E-05 |
NM_001123229 | insrb | insulin receptor b | −11.53691235 | 3.33E-05 |
NM_131381 | gsk3b | glycogen synthase kinase 3 beta | −11.65098191 | 1.87E-05 |
NM_199570 | calm3b | calmodulin 3b (phosphorylase kinase, delta) | −14.42999547 | 1.49E-11 |
NM_001077211 | mtor | mechanistic target of rapamycin (serine/threonine kinase) | −12.74710586 | 1.23E-07 |
NM_212710 | ppp1cab | protein phosphatase 1, catalytic subunit, alpha isozyme b | −4.868811067 | 1.31E-05 |
NM_199996 | calm2a | calmodulin2a (p hosphorylase kinase, delta) | −13.04988312 | 3.41E-08 |
NM_194402 | mknk2b | MAP kinase interacting serine/threonine kinase 2b | −14.02356489 | 1.26E-10 |
NM_214751 | pck1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 5.129531889 | 7.55E-09 |
NM_200315 | irs2a | insulin receptor substrate 2a | −12.51373347 | 4.75E-07 |
NM_201023 | prkacba | protein kinase, cAMP-dependent, catalytic, beta a | 4.638063399 | 9.62E-09 |
NM_205744 | braf | B-Raf proto-oncogene, serine/threonine kinase | −11.88966935 | 5.38E-06 |
NM_213035 | grb2b | growth factor receptor-bound protein 2b | −12.43630299 | 7.66E-07 |
NM_213076 | rps6kb1b | ribosomal protein S6 kinase b, polypeptide 1b | −11.31030831 | 6.05E-05 |
NM_213161 | prkag1 | protein kinase, AMP-activated, gamma 1 non-catalytic subunit | −11.20468266 | 0.000101616 |
NM_213252 | hk1 | hexokinase 1 | −13.41102831 | 3.67E-09 |
NM_001017732 | prkar1ab | protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b | −11.53493265 | 3.59E-05 |
NM_001077370 | prkar2aa | protein kinase, cAMP-dependent, regulatory, type II, alpha A | −4.330637539 | 1.19E-05 |
NM_001281844 | pik3r1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | −13.92572365 | 2.37E-10 |
NM_131721 | mapk8b | mitogen-activated protein kinase 8b | −5.355743879 | 1.18E-06 |
NM_001080066 | g6pc3 | glucose 6 phosphatase, catalytic, 3 | 4.465924297 | 9.85E-08 |