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Fig. 6 | BMC Genomics

Fig. 6

From: Improved recovery of cell-cycle gene expression in Saccharomyces cerevisiae from regulatory interactions in multiple omics data

Fig. 6

Cell-cycle GRNs based on important TF Features. (a, b) The GRNs consisting of TFs with the top 10th percentile weights for all cell-cycle expressed genes using TF-target interactions from ChIP (a), or Deletion (b) data. (c, d) The GRNs consisting of TFs in FFLs with the top 10th percentile weights for all cell-cycle expressed genes using ChIP (c) or deletion (d) data. Interactions are further annotated with the phase of cell-cycle expression they are important for (10th percentile of SVM weight in ChIP-chip models). Insert: Cell-cycle phase 1 = G1, 2 = S, 3 = S/G2, 4 = G2/M, 5 = M/G1. Red edges: new interactions identified compared to (c). In (a-d), node outline colors indicate TFs shared between GRNs in: orange - (a) and (b); pink - (a) and (c); blue – (b), (c), and (d); cyan - (c), and (d). Filled colors: four modules with TF-TF interactions important for expression in ≥2 phases. Red and green modules consist of known cell-cycle regulations, blue and purple modules consist of non-annotated cell cycle regulators

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