Table 3 Frequency and distribution of mutations associated with drug resistance M. tuberculosis
Drug | Target gene | mutation | n (%) in monoresistance | n (%) in MDR-TB strains | n (%) in other resistance pattern | Total (N) |
|---|---|---|---|---|---|---|
RIF (n = 27) | rpoB | S450L | 4 (14.8) | 16 (59.3) | 6 (22.2) | 26 |
D435Y | 1 (3.7) | 1 (3.7) | – | 1 | ||
INH (n = 55) | katG | S315T | 10 (18.2) | 24 (43.6) | 16 (29.1) | 50 |
S302R | – | 1 (1.8) | 1 (1.8) | 2 | ||
N138S | – | 1 (1.8) | – | 1 | ||
oxyR’-ahpC | C52T | – | 1 (1.8) | – | 1 | |
C54T | – | 1 (1.8) | – | 1 | ||
EMB (n = 29) | embB | Y319C | – | – | 1 (3.4) | 1 |
Q497R | – | 6 (20.9) | 2 (6.9) | 8 | ||
G406D | – | – | 1 (3.4) | 1 | ||
G406S | – | 2 (6.9) | 3 (10.3) | 5 | ||
M306L | – | 1 (3.4) | – | 1 | ||
M306I | – | 1 (3.4) | – | 1 | ||
G406A | – | 3 (10.3) | – | 3 | ||
M306V | – | 2 (6.9) | – | 2 | ||
Y334H | – | 1 (3.4) | – | 1 | ||
M306T | – | 1 (3.4) | – | 1 | ||
EmbC-embA | C16T | 1 | 1 (3.4) | 3 (10.3) | 5 | |
PZA (n = 19) | pncA | V128G | – | 8 (42.1) | – | 8 |
A193AT | – | – | 1 (5.3) | 1 | ||
G17D | – | – | 1 (5.3) | 1 | ||
D8N | 1 | – | – | 1 | ||
L85P | – | – | 1 (5.3) | 1 | ||
A46V | – | 1 (5.3) | – | 1 | ||
P69L | – | 1 (5.3) | – | 1 | ||
Q10R | – | 1 (5.3) | – | 1 | ||
D49G | – | 1 (5.3) | – | 1 | ||
D63A | – | 1 (5.3) | – | 1 | ||
Rv2044c | – | 1 (5.3) | 1 (5.3) | 2 | ||
STR (n = 3) | rpsL | K43R | – | 2 (100) | – | 2 |
rrs | C517T | – | 1 (100) | – | 1 | |
FLO (n = 1) | gyrB | R446C | – | 1 (100) | – | 1 |
AMK (n = 2) | rrs | C517T | – | 2 (100) | – | 2 |