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Fig. 4 | BMC Genomics

Fig. 4

From: Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons

Fig. 4

Some OR genes share 5′ UTR exons. (a) Transcript models for two human OR genes. Exons are depicted as boxes and introns as connecting lines. The arrowheads indicate the direction of transcription. The coding sequence is represented by taller, darker blue boxes. OR51E2 contains transcripts that splice across to the most 5′ exon of the adjacent OR51C1P gene. (b) Coverage plot of the aggregated RNAseq reads from this study (top; 9 samples) and from Olender et al. (bottom; 4 samples). Lines represent splice junctions and the number of supporting reads are indicated. (c) Further support for the splice junction spanning both genes can be found in several mRNA and EST clones deposited to GenBank; accession numbers are indicated. For each sequence, the red boxes represent alignments to the reference genome. (d) Same as in A-C but for the orthologous genes in the mouse genome. The sharing of 5′ UTR exons is supported by mRNA and EST clones from GenBank (derived from non-olfactory tissues), but is not observed in the RNAseq data from olfactory mucosa. The coverage plot is from the mouse RNAseq data of all 12 samples together

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