Table 8 GSEA identified equivalently changed pathways in the antidepressant data

Pathway

Signaling by GPCR

Class A/1 (Rhodopsin-like receptors)

Peptide ligand-binding receptors

GPCR downstream signaling

G alpha (i) signalling events

GPCR ligand binding

L13a-mediated translational silencing of Ceruloplasmin expression

Formation of a pool of free 40S subunits

GTP hydrolysis and joining of the 60S ribosomal subunit

G alpha (q) signalling events

G alpha (s) signalling events

SRP-dependent cotranslational protein targeting to membrane

Nonsense-Mediated Decay (NMD)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Protein-protein interactions at synapses

Dopamine Neurotransmitter Release Cycle

Serotonin Neurotransmitter Release Cycle

Glutamate Neurotransmitter Release Cycle

Synaptic adhesion-like molecules