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Fig. 2 | BMC Genomics

Fig. 2

From: Dynamic network inference and association computation discover gene modules regulating virulence, mycotoxin and sexual reproduction in Fusarium graminearum

Fig. 2

Gene Ontology (GO) annotation and transcriptional factor (TF) binding motifs enrichment in the predicted regulatory modules. GO enrichment was conducted for genes in each module, and major function associations were then assigned to each module using the most enriched GO terms. Each module is annotated with 55 main GO annotations (P-value < 0.05). The MEME algorithm was used to find TF motif enrichment in the 500-bp region upstream of the F. graminearum genes sequence for each module (E value <1e-5) followed by motif comparison with the budding yeast TF motif database using Tomtom (Methods). The heatmap on the left shows the significantly enriched GO terms per module; the color bar is scaled according to the P-value. A full description of the GO annotations is available in Additional file 11. The heatmap in the middle shows the motif enrichment results sorted into a total of 56 motifs; the color bar is scaled according to the E-value. The heatmap on the right shows the phenotype associations of each module based on association index analysis

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