Fig. 8
From: Insight into unique somitogenesis of yak (Bos grunniens) with one additional thoracic vertebra
Role of PP2A and TBLR1 in WNT/beta-catenin signaling pathway. a. beta-catenin is phosphorylated by the degradation complex (DC) with PP2A and HSP105 as its components, and it undergoes phosphorylation-dependent ubiquitination without the stimulus wnt and degraded by proteasome. b. The accumulation of beta-catenin induced by the stimulus wnt. c. The co-repressors TLE1 and HDAC1 repress the wnt target genes. d. TBL1-TBLR1 and beta-catenin recruit each to remove co-repressors TLE1 and HDAC1 and activate the transcription of wnt target genes. This figure is our own