Fig. 2

Selection signal and expression profiles of three representative genes associated with behavioral modification during domestication. These genes are both positively selected genes and differentially expressed genes in cerebrum or cerebellum in domesticated chickens, whose functions in domestication-related behavioral alterations have been verified in mutant mouse models. The left panels indicate statistics across different methods including Heterozygosity, Tajima’s D, Fay and Wu’s H, integrated haplotype score (iHS) and SweepFinder. The vertical axes represent the statistical values for each method; the horizontal axes represent the genomic coordinates around the target genes. The red dashed line in each method denotes the threshold above/below which the signals were considered as positive selection. The right panels illustrate the gene expression levels of cerebrum and cerebellum in wild and domesticated chickens, where the double asterisks represent significant difference with a P value < 0.01