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Fig. 2 | BMC Genomics

Fig. 2

From: Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics

Fig. 2

Multiple independent associations with MCH demonstrate complex genetic architecture at HBA1/HBA2 locus. All plots: each point represents one SNP; x-axis: increasing position on chromosome 16 left to right; y-axis: -log10(p-value) of the association with MCH. a Regional association plot of 14 independent associations in unadjusted analysis of multi-ethnic study population (n = 41,317). Large circles represent conditionally independent lead SNPs, labeled by rsid (order of conditioning is shown in Table 1); small colored SNPs represent variants in high LD (r2 > 0.8 in LD in pooled MEGA subpopulation) with the lead SNP of the corresponding color. b-d Locus-Zoom regional association plots of MCH association with rs60125383 (11th round of conditioning, purple diamond) in African Americans on an African American LD background (b n = 8703), Hispanics/Latinos on a Hispanic/Latino LD background (c, n = 17,380), and European Americans on a European LD background (d n = 14,707). SNP correlation with the lead SNP (r2) is colored according to the legend in (b). Annotated Refseq genes proximal to the lead SNP are shown by position above the X axis

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