Deep in the Bowel: Highly Interpretable Neural Encoder-Decoder Networks Predict Gut Metabolites from Gut Microbiome

Table 5 This table shows the average “out-of-the-box” AUC for binary classifiers trained on 25 randomly sub-sampled training sets

Feature Space	CD vs. HC	UC vs. HC	CD vs. UC	antibiotic	IST	mesalamine	steroids
Microbes only	0.944	0.741	0.784	0.822	0.713	0.582	0.693
Latent space only	0.932	0.759	0.764	0.866	0.731	0.646	0.670
Metabolites only	0.944	0.930	0.781	0.811	0.682	0.956	0.739
Microbes and metabolites	0.950	0.933	0.799	0.838	0.696	0.956	0.750
All layers	0.952	0.925	0.818	0.854	0.717	0.948	0.729

In most cases, the latent space classifier performs at least as well as the microbe classifier. Acronyms: CD Crohn’s disease; UC ulcerative colitis; HC healthy control; IST immunosuppressive therapy

ISSN: 1471-2164