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Fig. 7 | BMC Genomics

Fig. 7

From: The effect of antibiotics on the gut microbiome: a metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice

Fig. 7

A-C Relative abundance of enriched ARGs (CARD database; 36) that are statistically significant and differentially represented at all three timepoints (24, 48, or 72 h) in samples treated with antibiotics. Relative abundance of ARGs that were enriched and had a statistically significant change at any of the three timepoints (24, 48, or 72 h) after oral treatment with Ampicillin (A1, LImA23s ribosomal RNA methyltransferase; A2, efrB, a part of the EfrAB efflux pump; A3, parY mutant conferring resistance to aminocoumarin), Ciprofloxacin (B1,Bifidobacterium adolescentis rpoB conferring resistance to rifampicin; B2, Nocardia rifampin resistant beta-subunit of RNA polymerase (rpoB2); B3, Streptomyces rishiriensis parY mutant conferring resistance to aminocoumarin), or Fosfomycin (C1, ugd, required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A; C2, cmeB, the inner membrane transporter of the CmeABC multidrug efflux complex; C3, mupB, an alternative isoleucyl-tRNA synthetase conferring resistance to mupirocin) are shown. The height of each bar corresponds to the average relative abundance of ARG for that specific timepoint. The relative abundance was calculated as the percentage of reads mapped to each ARG within the sample. Statistically significant change of relative abundance was defined as those pairwise comparisons between control and any time points with an FDR < =0.05 (* FDR < =0.05, ** FDR < = 0.01, *** FDR < = 0.001, **** FDR < = 0.0001). Only representative ARGs are shown. The full list can be found in Table 2

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