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Fig. 8 | BMC Genomics

Fig. 8

From: The effect of antibiotics on the gut microbiome: a metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice

Fig. 8

a-c Principle Coordinate Analysis (PCoA) based on Bray–Curtis dissimilarity of ARG abundances between samples reveals the time-dependent shift of antibiotic resistant gene (ARG) profiles after oral treatment with Ampicillin (a), Ciprofloxacin (b), or Fosfomycin (c). For each antibiotic cohort, the first and second principle components are shown on X and Y axis, respectively. For all three cohorts, there was a general trend that control samples grouped together along either the X and/or Y axis, indicating control samples had similar profiles of ARG. All treatment samples for Ciprofloxacin and Fosfomycin clustered along the Y axis away from control samples indicating a dramatic shift in the ARG profiles compared to control samples. On the other hand, Ampicillin treated samples showed a gradual shift in ARG profiles with 24-h treatment samples clustering along with controls, 48-h samples scattered in the middle and 72-h samples clustered at the other end of the plot

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