Table 4 The top 10 KEGG pathways with the highest enrichment of DEGs in groups with different immune challenges
Pathway ID | DEGs annotation in the pathway | All genes annotation in the pathway | P-values | Pathway annotation |
|---|---|---|---|---|
CT-vs-LPS | ||||
 ko02010 | 40 (3.26%) | 163 (1.07%) | 1.040587e-10 | ABC transporters |
 ko04120 | 41 (3.34%) | 274 (1.79%) | 7.710349e-05 | Ubiquitin mediated proteolysis |
 ko00250 | 15 (1.22%) | 88 (0.58%) | 0.004140363 | Alanine, aspartate and glutamate metabolism |
 ko05215 | 21 (1.71%) | 147 (0.96%) | 0.006927921 | Prostate cancer |
 ko00512 | 7 (0.57%) | 30 (0.2%) | 0.008355145 | Mucin type O-glycan biosynthesis |
 ko04919 | 43 (3.5%) | 374 (2.45%) | 0.01077703 | Thyroid hormone signaling pathway |
 ko05226 | 30 (2.44%) | 247 (1.62%) | 0.01495566 | Gastric cancer |
 ko04330 | 28 (2.28%) | 227 (1.49%) | 0.01511225 | Notch signaling pathway |
 ko04975 | 12 (0.98%) | 76 (0.5%) | 0.01751861 | Fat digestion and absorption |
 ko00562 | 15 (1.22%) | 105 (0.69%) | 0.0203857 | Inositol phosphate metabolism |
CT-vs-PIC | ||||
 ko00562 | 22 (1.45%) | 105 (0.69%) | 0.0005556445 | Inositol phosphate metabolism |
 ko04214 | 30 (1.98%) | 167 (1.09%) | 0.0009830988 | Apoptosis – fly |
 ko04922 | 26 (1.71%) | 138 (0.9%) | 0.001015626 | Glucagon signaling pathway |
 ko04630 | 23 (1.52%) | 124 (0.81%) | 0.002380328 | Jak-STAT signaling pathway |
 ko05223 | 19 (1.25%) | 100 (0.65%) | 0.004151803 | Non-small cell lung cancer |
 ko04070 | 24 (1.58%) | 142 (0.93%) | 0.006645948 | Phosphatidylinositol signaling system |
 ko00564 | 25 (1.65%) | 151 (0.99%) | 0.007416318 | Glycerophospholipid metabolism |
 ko00520 | 15 (0.99%) | 78 (0.51%) | 0.009115605 | Amino sugar and nucleotide sugar metabolism |
 ko05211 | 21 (1.38%) | 124 (0.81%) | 0.01041359 | Renal cell carcinoma |
 ko04120 | 39 (2.57%) | 274 (1.79%) | 0.0137763 | Ubiquitin mediated proteolysis |
CT-vs-VH | ||||
 ko02010 | 24 (2.33%) | 163 (1.07%) | 0.0002372665 | ABC transporters |
 ko04922 | 20 (1.94%) | 138 (0.9%) | 0.0009303992 | Glucagon signaling pathway |
 ko04931 | 22 (2.14%) | 169 (1.11%) | 0.002216142 | Insulin resistance |
 ko04520 | 24 (2.33%) | 197 (1.29%) | 0.00347834 | Adherens junction |
 ko04711 | 4 (0.39%) | 11 (0.07%) | 0.004603775 | Circadian rhythm – fly |
 ko04710 | 7 (0.68%) | 35 (0.23%) | 0.007846637 | Circadian rhythm |
 ko00562 | 14 (1.36%) | 105 (0.69%) | 0.01068485 | Inositol phosphate metabolism |
 ko01523 | 13 (1.26%) | 95 (0.62%) | 0.01105092 | Antifolate resistance |
 ko00534 | 10 (0.97%) | 65 (0.43%) | 0.01116436 | Glycosaminoglycan biosynthesis-heparan sulfate / heparin |
 ko04962 | 10 (0.97%) | 65 (0.43%) | 0.01116436 | Vasopressin-regulated water reabsorption |