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Table 4 The top 10 KEGG pathways with the highest enrichment of DEGs in groups with different immune challenges

From: Transcriptomic analysis of sea cucumber (Holothuria leucospilota) coelomocytes revealed the echinoderm cytokine response during immune challenge

Pathway IDDEGs annotation in the pathwayAll genes annotation in the pathwayP-valuesPathway annotation
CT-vs-LPS
ko0201040 (3.26%)163 (1.07%)1.040587e-10ABC transporters
ko0412041 (3.34%)274 (1.79%)7.710349e-05Ubiquitin mediated proteolysis
ko0025015 (1.22%)88 (0.58%)0.004140363Alanine, aspartate and glutamate metabolism
ko0521521 (1.71%)147 (0.96%)0.006927921Prostate cancer
ko005127 (0.57%)30 (0.2%)0.008355145Mucin type O-glycan biosynthesis
ko0491943 (3.5%)374 (2.45%)0.01077703Thyroid hormone signaling pathway
ko0522630 (2.44%)247 (1.62%)0.01495566Gastric cancer
ko0433028 (2.28%)227 (1.49%)0.01511225Notch signaling pathway
ko0497512 (0.98%)76 (0.5%)0.01751861Fat digestion and absorption
ko0056215 (1.22%)105 (0.69%)0.0203857Inositol phosphate metabolism
CT-vs-PIC
ko0056222 (1.45%)105 (0.69%)0.0005556445Inositol phosphate metabolism
ko0421430 (1.98%)167 (1.09%)0.0009830988Apoptosis – fly
ko0492226 (1.71%)138 (0.9%)0.001015626Glucagon signaling pathway
ko0463023 (1.52%)124 (0.81%)0.002380328Jak-STAT signaling pathway
ko0522319 (1.25%)100 (0.65%)0.004151803Non-small cell lung cancer
ko0407024 (1.58%)142 (0.93%)0.006645948Phosphatidylinositol signaling system
ko0056425 (1.65%)151 (0.99%)0.007416318Glycerophospholipid metabolism
ko0052015 (0.99%)78 (0.51%)0.009115605Amino sugar and nucleotide sugar metabolism
ko0521121 (1.38%)124 (0.81%)0.01041359Renal cell carcinoma
ko0412039 (2.57%)274 (1.79%)0.0137763Ubiquitin mediated proteolysis
CT-vs-VH
ko0201024 (2.33%)163 (1.07%)0.0002372665ABC transporters
ko0492220 (1.94%)138 (0.9%)0.0009303992Glucagon signaling pathway
ko0493122 (2.14%)169 (1.11%)0.002216142Insulin resistance
ko0452024 (2.33%)197 (1.29%)0.00347834Adherens junction
ko047114 (0.39%)11 (0.07%)0.004603775Circadian rhythm – fly
ko047107 (0.68%)35 (0.23%)0.007846637Circadian rhythm
ko0056214 (1.36%)105 (0.69%)0.01068485Inositol phosphate metabolism
ko0152313 (1.26%)95 (0.62%)0.01105092Antifolate resistance
ko0053410 (0.97%)65 (0.43%)0.01116436Glycosaminoglycan biosynthesis-heparan sulfate / heparin
ko0496210 (0.97%)65 (0.43%)0.01116436Vasopressin-regulated water reabsorption