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Table 1 Homozygous mutations of genes in MT strain

From: Genomic analysis of a riboflavin-overproducing Ashbya gossypii mutant isolated by disparity mutagenesis

ChromosomePositionWT seq.MT seq.QualityMutationGeneProductDNA changesProtein changesNumber
WT seq.MT seq.
II496,139CT1495.42missenseAGOS_ABR055CTranscriptional activator (AgSOK2 or AgPHD1)c.1180G > AG394R038
III726,948CGC1167.38frameshiftAGOS_ACR215CCytosolic serine hydroxymethyltransferase (AgSHM2)c.1332delCp.Q445fs030
IV1,433,004TA1442.42missenseAGOS_ADR404COleate-activated transcription factor (AgOAF1 or AgPIP2)c.2317A > Tp.T773S038
IV1,433,040TG1455.42missenseAGOS_ADR404COleate-activated transcription factor (AgOAF1 or AgPIP2)c.2281A > Cp.T761P039
IV199,365GA1523.42missenseAGOS_ADL287CChorismate synthase (AgARO2)ac.206C > Tp.T69M039
V70,024CA1836.42missenseAGOS_AEL305CLarge subunit of acetohydroxyacid synthase (AgILV2)ac.1365G > Tp.Q455H046
VII791,717CA1505.42missenseAGOS_AGL123WCytidine deaminase (AgCDD1)c.314C > Ap.P105Q041
VII962,069GA1560.42nonsenseAGOS_AGL036CHeat shock protein 104 (AgHSP104)c.1066C > Tp.Q356*042
VI1,753,850GA1884.42missenseAGOS_AGR382WL-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AgLYS5)c.365G > Ap.R122H049
  1. These homozygous mutations are a subset among all 32 homozygous mutations which are shown in Table S1
  2. aFlavoproteins
  3. *Translation stops here