Fig. 3
From: Lung transcriptomic clock predicts premature aging in cigarette smoke-exposed mice
CS-exposed mice and highly irradiated mice are predicted to be prematurely aged. a. Chronological age versus predicted age for sham- and CS-exposed mice from E-MTAB-5281, E-MTAB-5280 and E-MTAB-7444 datasets. b. Boxplots summarizing the residuals (predicted age minus chronological age) for the same datasets. c. Age predictions of samples from an independent public dataset (GSE18344) where CD-1 mice where exposed to different daily doses of CS over 5 months. d and e. Prediction from the model applied to lung transcriptomes from the public dataset GSE41789. Age predictions were computed for 3 groups of mice; untreated mice and mice irradiated to 5 Gy or 17.5 Gy. Only 17.5 Gy induced lung fibrosis, senescence, and marks of accelerated aging according to the original study. Significance levels for t-test are indicated for each comparison (**** P < 0.0001; *** P < 0.001; ** P < 0.01; * P < 0.05;. P < 0.1; ns P > 0.1). The p-value from one-way anova test comparing all the groups is indicated