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Table 3 All enriched KEGG pathway-based sets of differentially expressed genes (DEGs) in between RFI groups

From: Identification of key genes and pathways associated with feed efficiency of native chickens based on transcriptome data via bioinformatics analysis

Signaling pathways

Count

B-H P-value

Genesa

Phagosome

17

0.0001

TLR4, TUBB6, BF2, NCF4, BLB1, CYBB, TLR2B, THBS1, BLB2, ACTB, CTSS, ITGB2, DMB2, TAP1, TAP2, LOC100859737, YF5

Cell adhesion molecules (CAMs)

15

0.0003

BF2, BLB1, ICOS, BLB2, CD8BP, ITGA8, ITGB2, PTPRC, NLGN1, DMB2, YF5, ITGA4, VCAM1, PDCD1LG2

Intestinal immune network for IgA production

8

0.0003

BLB1, ICOS, AICDA, BLB2, TNFSF13B, DMB2, ITGA4

Cytokine-cytokine receptor interaction

18

0.0003

TNFRSF18, FASLG, XCR1, EDA2R, IL18R1, CSF2RA, TNFSF13B, CCL1, CCR2, IL4R, TNFRSF8, IL18, TNFRSF4, IL17RA, IL22RA2, IL1RAP, TNFRSF25, TNFSF4

Oxidative phosphorylation

11

0.0065

ND1, ND2, ND3, ND4, ND4L, ND5, CYTB, COX1, COX2, COX3, ATP6

Toll-like receptor signaling pathway

9

0.0140

TLR4, TLR2B, SPP1, TRAF3, PIK3CB, STAT1, PIK3R5, PIK3CD, TLR1B

Jak-STAT signaling pathway

11

0.0353

CSF2RA, SOCS3, JAK3, PIM1, PIK3CB, STAT1, IL4R, PIK3R5, PIK3CD, IL22RA2, PTPN6

Regulation of actin cytoskeleton

13

0.0412

TMSB4X, ARPC5, RAC2, ITGA8, ACTB, PIK3CB, IQGAP2, ITGB2, ARPC1B, PIK3R5, PIK3CD, CYFIP2, ITGA4

  1. a Up-regulated genes in LRFI birds are highlighted in bold and down-regulated genes in normal typeface