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Table 6 Gene set enrichment analysis (GSEA) between HRFI and LRFI birds

From: Identification of key genes and pathways associated with feed efficiency of native chickens based on transcriptome data via bioinformatics analysis

Gene setNESaFDRbHigher expression in HRFI or LRFI
GO-based list (C5, CC, C5.BP, C5.MP)
 GO:0044455Mitochondrial membrane part2.60< 0.001LRFI
 GO:0022900Electron transport chain2.090.011LRFI
 GO:0010822Positive regulation of mitochondrion organization1.800.027LRFI
 GO:0005740Mitochondrial envelope1.820.029LRFI
 GO:0009205Purine ribonucleoside triphosphate metabolic process1.850.031LRFI
 GO:0009144Purine nucleoside triphosphate metabolic process1.910.034LRFI
 GO:0046034ATP metabolic process1.850.039LRFI
 GO:0001960Negative regulation of cytokine-mediated signaling pathway−1.770.010HRFI
 GO:0060761Negative regulation of response to cytokine stimulus−1.760.011HRFI
 GO:0070588Calcium ion transmembrane transport−1.740.012HRFI
 GO:1903169Regulation of calcium ion transmembrane transport− 1.730.015HRFI
 GO:0042439Ethanolamine-containing compound metabolic process−1.710.019HRFI
 GO:0001776Leukocyte homeostasis−1.700.022HRFI
 GO:0008625Extrinsic apoptotic signaling pathway via death domain receptors−1.700.023HRFI
KEGG-based list (C2.CP:KEGG)
 KO00020Citrate cycle (TCA cycle)2.280.005LRFI
 KO04260Cardiac muscle contraction1.700.031LRFI
 KO04672Intestinal immune network for IgA production−1.600.020HRFI
 KO00510N-Glycan biosynthesis−1.570.022HRFI
 KO00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate−1.520.040HRFI
  1. a NES normalized enriched score
  2. b FDR false discovery rate
  3. Positive and negative NES indicate higher and lower expression in LRFI, respectively