Being red, blue and green: the genetic basis of coloration differences in the strawberry poison frog (Oophaga pumilio)

Table 3 Color-associated genes with SNPs showing signatures of directional selection among the three color phenotypes of O. pumilio studied

SNP	alleles	q-value	alpha	F_st	gene	Link to pigmentation
pasa_150225:833	C/T	0.042	1.396	0.447	mpzl3_2	severe skin and hair abnormalities in mice (p)
pasa_255433:3485	G/A	0.032	1.623	0.498	fzd6_1	melanin synthesis (p)
pasa_343423:2249	C/A	0.002	1.916	0.561	hba2	hyperpigmented human skin
pasa_343423:2449	A/G	0.002	1.940	0.567	hba2	hyperpigmented human skin
pasa_394127:2961	C/T	0.046	1.387	0.445	med1	retinal pigmentation
pasa_398461:1237	G/A	0.006	1.795	0.535	rxrb_1	carotenoid metabolism (p)
pasa_45399:7303	C/T	0.018	1.718	0.518	unc119	retinal pigmentation
pasa_533653:4303	G/A	0.002	1.935	0.566	kit	melanin synthesis
pasa_533653:4362	A/T	0.003	1.922	0.563	kit	melanin synthesis
pasa_533653:4575	G/A	0.002	1.919	0.562	kit	melanin synthesis
pasa_533653:5276	A/C	0.002	1.935	0.565	kit	melanin synthesis
pasa_534292:953	G/A	0.007	1.755	0.526	rdh12_3	carotenoid metabolism (p)

For each SNP entry, the position and alternative alleles, as well as BayeScan results (posterior probability, q-value, alpha, F_st) are presented along with the gene symbol and potential link to pigmentation. Gene symbols followed by underscore and a number represent potential paralogs and their functions (p) are less reliable

ISSN: 1471-2164