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Table 3 DMGs most likely involved in muscle development

From: Analysis of DNA methylation profiles during sheep skeletal muscle development using whole-genome bisulfite sequencing

 RNA-seq dataWGBS-seq data
Gene nameFPKM of FetusFPKM of Adultlog2FCMethChrMethDiff (FetusV Adult)P-valueAnnotation
ADIPOQ2.7 ± 0.7059.02 ± 8.375.071 (198577572–198,577,648)0.3551.95E-13Distal Intergenic
CCNA23.96 ± 1.320.22 ± 0.04−3.536 (3651607–3,651,817)0.4948.16E-19Intron
ITGA16.3 ± 2.320.22 ± 0.06−4.2016 (26099670–26,099,819)−0.3741.02E-08Intron
MYOG118.2 ± 11.468.76 ± 1.99−3.1512 (196054–196,192)−0.4092.76E-07Exon
12 (220130–220,377)−0.3144.32E-09Distal Intergenic
12 (229114–229,232)0.547.28E-07Distal Intergenic
MAPT1.08 ± 0.276.49 ± 1.043.2311 (45304861–45,304,888)−0.4186.01E-08Distal Intergenic
11 (45312449–45,312,737)−0.3081.53E-10Promoter (2-3 kb)
11 (45313729–45,313,893)−0.344.93E-09Promoter (1-2 kb)
11 (45317381–45,317,584)0.3994.47E-20Intron
11 (45327134–45,327,228)−0.5196.13E-12Intron
11 (45328297–45,328,427)−0.3721.50E-07Intron
11 (45345547–45,345,760)−0.3689.78E-08Intron
11 (45360455–45,360,557)0.3712.30E-07Intron
11 (45379302–45,379,326)−0.3741.46E-08Intron
11 (45380382–45,380,415)−0.4138.46E-09Intron
11 (45390429–45,390,641)0.3684.67E-06Intron
11 (45398919–45,399,057)0.3712.28E-08Intron
11 (45434897–45,434,935)0.5224.15E-08Distal Intergenic
DIAPH11.79 ± 0.129.73 ± 1.473.085 (50071804–50,071,997)−0.3822.45E-16Intron
5 (50074050–50,074,580)− 0.3433.12E-15Intron
5 (50078005–50,078,016)−0.5159.21E-17Intron
5 (50093277–50,093,488)−0.514.68E-11Promoter (1-2 kb)
NR4A11.9 ± 0.6446.14 ± 5.865.203 (134110748–134,110,763)−0.4624.49E-10Distal Intergenic
3 (134112701–134,112,875)−0.41.53E-08Intron
3 (134118207–134,118,238)−0.4743.23E-06Promoter (1-2 kb)
DLK1123.79 ± 16.791.59 ± 0.18−5.6218 (64227388–64,227,489)0.3154.53E-06Distal Intergenic
18 (64229987–64,230,060)0.5661.12E-11Distal Intergenic
18 (64285447–64,285,772)0.3152.15E-09Distal Intergenic
18 (64297875–64,297,887)0.5092.27E-07Distal Intergenic
18 (64322164–64,322,397)0.3037.14E-08Distal Intergenic
18 (64325751–64,325,850)0.312.10E-05Promoter (2-3 kb)
18 (64332000–64,332,064)0.3615.28E-05Exon
18 (64374254–64,374,306)0.3722.43E-05Distal Intergenic
18 (64374640–64,374,824)0.5672.60E-33Distal Intergenic
18 (64379476–64,379,559)0.4181.43E-05Distal Intergenic
COL1A21509.82 ± 168.72166.04 ± 40.84−2.534 (11479735–11,479,933)0.3161.92E-05Distal Intergenic
4 (11513253–11,513,266)−0.372.60E-06Distal Intergenic
4 (11551771–11,551,783)0.4332.40E-08Distal Intergenic
4 (11553777–11,553,809)0.3347.76E-06Distal Intergenic
4 (11712184–11,712,329)0.3095.19E-12Distal Intergenic
  1. Note: chr: chromosome. DMR: different methylated regions. Meth diff: the difference in methylation levels between Fetus and Adult; a positive number means the methylation levels of this region in the Adult group are higher than those in the Fetus group, and a negative number means that the methylation levels of this region in the Adult group are lower than those in the Fetus group