Fig. 6

Proposed model for the cnidarian circadian clock composed of two loops adapted from Reitzel et al. [13] and associated behavior. This proposed network combines the positive elements (center), the feed-forward loop (left), and the feedback loop (right). The positive elements, Clock and Cycle heterodimerize (CLOCK:CYCLE) and upregulate genes in the feed-forward and feedback loops (PAR-bZIPs and cryptochromes, respectively) where they act as transcriptional regulators for the positive elements. CIPC is a predicted repressor of the CLOCK:CYCLE protein complex based on data from vertebrates. Differential expression (DE) of genes in this network are indicated with solid (DE) or dashed (not DE) lines for each color (key far left). Cycle is not outlined because this gene was not differentially expressed in any condition. Plots of behavioral responses to each wavelength are shown on the far right as cartoons