Fig. 1

The diagram of our precise prediction models. The CG with yellow color represents the feature locus, the CG with blue color represents the model locus. And the shade of the color indicates the methylation level, the dark color represents hyper-methylation, the light color represents hypo-methylation. The CpG loci covered by EPIC array but not included in 450 K array were defined as the model loci, the loci covered by both EPIC and 450 K array were defined as the feature loci. PretiMeth accurately predicts the methylation levels of model loci by the methylation levels of feature loci