Fig. 5

Significant correspondence between epigenetic dynamics and expression dynamics. a Venn diagrams displaying the number of common and direction-specific EDGs and DEGs during differentiation from H1 to MSC or NPC, respectively. The arrows indicate the three gene set pairs to be tested for the degree of gene overlap. b Bar plot showing the proportions of DEGs in the corresponding EDGs. These proportions from observed data were clearly significantly (P < 0.001) different from those from randomly permutated data. The simulated results are presented as the mean ± sd. c Bubble chart showing the GO terms enriched for the three sets of EDGs. Dot sizes are scaled to the enrichment significance