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Table 3 Functional enrichment for GCS-score results for dataset: GSE103380. Top GO categories returned from ToppFun Suite

From: GCSscore: an R package for differential gene expression analysis in Affymetrix/Thermo-Fisher whole transcriptome microarrays

Category

ID

Name

p-value

FDR (B&H)

GO: Molecular Function

GO:0003723

RNA binding

1.11E-10

1.18E-07

GO: Molecular Function

GO:0017076

purine nucleotide binding

5.01E-08

2.16E-05

GO: Molecular Function

GO:0003735

structural constituent of ribosome

6.07E-08

2.16E-05

GO: Molecular Function

GO:0032555

purine ribonucleotide binding

1.48E-07

3.93E-05

GO: Molecular Function

GO:0032553

ribonucleotide binding

2.09E-07

4.45E-05

GO: Biological Process

GO:0044403

symbiotic process

1.16E-35

6.36E-32

GO: Biological Process

GO:0016032

viral process

2.25E-35

6.36E-32

GO: Biological Process

GO:0044419

interspecies interaction between organisms

1.03E-34

1.93E-31

GO: Biological Process

GO:0051707

response to other organism

2.90E-32

3.06E-29

GO: Biological Process

GO:0009607

response to biotic stimulus

3.08E-32

3.06E-29

GO: Biological Process

GO:0043207

response to external biotic stimulus

3.25E-32

3.06E-29

GO: Biological Process

GO:0098542

defense response to other organism

9.85E-32

7.95E-29

GO: Biological Process

GO:0045087

innate immune response

3.58E-31

2.53E-28

GO: Biological Process

GO:0006952

defense response

4.28E-28

2.69E-25

GO: Biological Process

GO:0002252

immune effector process

3.18E-26

1.80E-23

GO: Cellular Component

GO:0022626

cytosolic ribosome

1.48E-15

1.01E-12

GO: Cellular Component

GO:0005840

ribosome

2.06E-10

5.84E-08

GO: Cellular Component

GO:0044391

ribosomal subunit

2.57E-10

5.84E-08

GO: Cellular Component

GO:0005764

lysosome

4.85E-10

6.90E-08

GO: Cellular Component

GO:0000323

lytic vacuole

5.05E-10

6.90E-08

Mouse Phenotype

MP:0005025

abnormal response to infection

5.88E-18

1.32E-14

Mouse Phenotype

MP:0001793

altered susceptibility to infection

7.44E-18

1.32E-14

Mouse Phenotype

MP:0002406

increased susceptibility to infection

3.38E-16

4.01E-13

Mouse Phenotype

MP:0020185

altered susceptibility to viral infection

1.27E-14

1.13E-11

Mouse Phenotype

MP:0002418

increased susceptibility to viral infection

2.17E-14

1.55E-11

Pathway

1,269,311

Interferon Signaling

1.95E-19

3.36E-16

Pathway

1,269,310

Cytokine Signaling in Immune system

4.81E-15

3.38E-12

Pathway

1,269,312

Interferon alpha/beta signaling

5.86E-15

3.38E-12

Pathway

1,269,108

Influenza Infection

3.72E-14

1.61E-11

Pathway

1,268,686

GTP hydrolysis and joining of the 60S ribosomal subunit

3.13E-13

7.91E-11

Disease

C0023893

Liver Cirrhosis, Experimental

1.08E-13

4.66E-10

Disease

C0042769

Virus Diseases

1.34E-12

2.89E-09

Disease

C0021400

Influenza

7.78E-12

9.47E-09

Disease

C0024141

Lupus Erythematosus, Systemic

8.76E-12

9.47E-09

Disease

C0019196

Hepatitis C

4.01E-11

2.90E-08