Table 2 GO enrichment analysis- biological processes (BP) terms of the set of differentially methylated loci for treated and untreated workers at 10% methylation difference threshold

GO:0030423

Inf

1

1

targeting of mRNA for destruction involved in RNA interference

GO:0007274

31.976

2

35

neuromuscular synaptic transmission

GO:0042062

496.625

1

2

long-term strengthening of neuromuscular junction

GO:0055083

248.281

1

3

monovalent inorganic anion homeostasis

GO:0072505

248.281

1

3

divalent inorganic anion homeostasis

GO:0072506

248.281

1

3

trivalent inorganic anion homeostasis

GO:0007415

248.281

1

3

defasciculation of motor neuron axon

GO:0030643

248.281

1

3

cellular phosphate ion homeostasis

GO:0030002

165.500

1

4

cellular anion homeostasis

GO:1990034

165.500

1

4

calcium ion export across plasma membrane

GO:0008038

14.791

2

73

neuron recognition

GO:0044205

124.109

1

5

‘de novo’ UMP biosynthetic process

GO:0043102

124.109

1

5

amino acid salvage

GO:0032728

124.109

1

5

positive regulation of interferon-beta production

GO:0019509

124.109

1

5

L-methionine salvage from methylthioadenosine

GO:0006796

3.750

7

1257

phosphate-containing compound metabolic process

GO:0071265

99.275

1

6

L-methionine biosynthetic process

GO:0048790

99.275

1

6

maintenance of presynaptic active zone structure

GO:0006309

82.719

1

7

apoptotic DNA fragmentation

GO:0031054

82.719

1

7

pre-miRNA processing

GO:0006207

70.893

1

8

‘de novo’ pyrimidine nucleobase biosynthetic process

GO:0046049

70.893

1

8

UMP metabolic process

GO:0007026

70.893

1

8

negative regulation of microtubule depolymerization

GO:0007482

70.893

1

8

haltere development

GO:0031629

70.893

1

8

synaptic vesicle fusion to presynaptic active zone membrane

GO:0046475

62.023

1

9

glycerophospholipid catabolic process

GO:0009174

62.023

1

9

pyrimidine ribonucleoside monophosphate biosynthetic process

GO:0006921

55.125

1

10

cellular component disassembly involved in execution phase of apoptosis

GO:0030422

55.125

1

10

production of siRNA involved in RNA interference

GO:0051693

55.125

1

10

actin filament capping

GO:0009129

49.606

1

11

pyrimidine nucleoside monophosphate metabolic process

GO:0007317

45.091

1

12

regulation of pole plasm oskar mRNA localization

GO:0000097

45.091

1

12

sulfur amino acid biosynthetic process

GO:0072499

41.328

1

13

photoreceptor cell axon guidance

GO:0016081

41.328

1

13

synaptic vesicle docking

GO:0030834

41.328

1

13

regulation of actin filament depolymerization

GO:0006555

38.144

1

14

methionine metabolic process

GO:0046112

38.144

1

14

nucleobase biosynthetic process

GO:0046132

38.144

1

14

pyrimidine ribonucleoside biosynthetic process

GO:1903779

38.144

1

14

regulation of cardiac conduction

GO:0006206

33.050

1

16

pyrimidine nucleobase metabolic process

GO:0009067

33.050

1

16

aspartate family amino acid biosynthetic process

GO:0009220

33.050

1

16

pyrimidine ribonucleotide biosynthetic process

GO:0002028

30.980

1

17

regulation of sodium ion transport

GO:0051290

30.980

1

17

protein heterotetramerization

GO:0043242

29.154

1

18

negative regulation of protein complex disassembly

GO:1905879

27.531

1

19

regulation of oogenesis

GO:0006213

27.531

1

19

pyrimidine nucleoside metabolic process

GO:0031050

27.531

1

19

dsRNA processing

GO:0032272

24.772

1

21

negative regulation of protein polymerization

GO:0008333

22.514

1

23

endosome to lysosome transport