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Table 2 SNPs demonstrating significant association with CHD in nined different breeds

From: An across-breed validation study of 46 genetic markers in canine hip dysplasia

Breed (N in analysis)

SNPs with significant associations with CHD

Location in CanFam3.1

Reference

Allele (minor / major)

OR (95% CI)

P-values: raw / permuted

Finnish Lapphund(303)

HD_25_51006290

ss7212922151

ss7212922146

ss7212922122

ss7212922154

CFA25: 47983231

CFA26: 14157064

CFA33: 4052295

CFA33: 7967486

CFA34: 11240092

[12]

[7]

[8]

[8]

[8]

G/A

T/C

C/T

C/T

A/G

5.56 [1.22–25.28]

1.63 [1.14–2.33]

1.50 [1.09–2.07]

0.68 [0.49–0.94]

0.67 [0.48–0.92]

0.013 / 0.021 a

6.8 × 10–03 / 9.7 × 10–03 a

0.013 / 0.012 a

0.019 / 0.021 a

0.015 / 0.019 a

Golden Retriever(235)

ss7212922155

ss7212922147

ss7212922135

CFA11: 54489194

CFA12: 16410934

CFA14: 56572744

[4]

[11]

[6]

G/A

A/G

T/C

0.57 [0.37–0.89]

0.56 [0.33–0.97]

1.55 [1.02–2.35]

0.014 / 0.013 b

0.037 / 0.033 b

0.040 / 0.034 b

Lagotto Romagnolo(194)

ss7212922120

ss7212922155

ss7212922151

CFA1: 45382633

CFA11: 54489194

CFA26: 14157064

[13]

[4]

[7]

C/Ac

G/A

T/C

0.59 [0.36–0.95]

0.60 [0.38–0.94]

2.00 [1.08–3.71]

0.029 / 0.028 a

0.025 / 0.040 a

0.025 / 0.028 a

Samoyed(149)

ss7212922144

ss7212922163

CFA3: 40302288

CFA24: 25973438

[11]

[7]

A/G

C/G

0.47 [0.28–0.78]

1.75 [1.06–2.90]

3.2 × 10–03 / 7.3 × 10–03 a

0.029 / 0.033 a

Spanish Water dog(114)

ss7212922131

ss7212922122

CFA21: 40146141

CFA33: 7967486

[10]

[8]

C/T

C/T

0.51 [0.29–0.89]

0.48 [0.25–0.90]

0.017 / 0.014 b

0.023 / 0.022 b

Great Dane(113)

ss7212922137

ss7212922133

CFA1: 46279297

CFA14: 20864104

[13]

[6]

G/A

C/G

2.14 [1.15–3.97]

5.07 [1.04–24.73]

0.016 / 0.017 b

0.045 / 0.036 b

Labrador Retriever(100)

ss7212922118

ss7212922126

ss7212922153

ss7212922141

ss7212922163

ss7212922154

CFA1: 45161186

CFA1: 67883139

CFA1: 67942900

CFA11: 29908777

CFA24: 25973438

CFA34: 11240092

[13]

[9]

[9]

[4]

[7]

[8]

C/G

A/T

T/A

A/T

G/C

G/A

1.83 [1.01–3.29]

2.51 [1.09–5.74]

2.55 [1.11–5.86]

0.47 [0.25–0.87]

1.87 [1.07–3.28]

0.52 [0.27–0.97]

0.046 / 0.037 b

0.030 / 0.023 b

0.027 / 0.020 b

0.016 / 0.017 b

0.029 / 0.023 b

0.040 / 0.027 b

Karelian Bear dog(97)

ss7212922161

ss7212922156

ss7212922152

ss7212922155

CFA1: 67876393

CFA8: 28489063

CFA8: 28489546

CFA11: 54489194

[12]

[12]

[12]

[4]

A/C

T/C

A/C

A/G

0.46 [0.23–0.91]

0.41 [0.17–0.96]

0.41 [0.17–0.96]

2.94 [1.41–6.10]

0.025 / 0.019 b

0.041 / 0.035 b

0.041 / 0.035 b

3.9 × 10–03 / 4.3 × 10–03 b

Finnish Hound (102)

ss7212922123

CFA17: 45022358

[4]

T/G

2.38 [1.31–4.34]

4.1 × 10–03 / 8.7 × 10–03 a

  1. aX2-test. bLogistic regression. CI confidence interval; OR odds ratio. The odds ratios and their confidence intervals were calculated by PLINK using default settings in which the minor allele increases the risk when OR > 1. The reference genome used in this study is CanFam3.1. cNo significant associations were observed in Bernese Mountain dogs. dMajor/minor allele designation of ss7212922120 is changed in Lagotto Romagnolo cohort