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Table 2 SNPs demonstrating significant association with CHD in nined different breeds

From: An across-breed validation study of 46 genetic markers in canine hip dysplasia

Breed (N in analysis) SNPs with significant associations with CHD Location in CanFam3.1 Reference Allele (minor / major) OR (95% CI) P-values: raw / permuted
Finnish Lapphund(303) HD_25_51006290
ss7212922151
ss7212922146
ss7212922122
ss7212922154
CFA25: 47983231
CFA26: 14157064
CFA33: 4052295
CFA33: 7967486
CFA34: 11240092
[12]
[7]
[8]
[8]
[8]
G/A
T/C
C/T
C/T
A/G
5.56 [1.22–25.28]
1.63 [1.14–2.33]
1.50 [1.09–2.07]
0.68 [0.49–0.94]
0.67 [0.48–0.92]
0.013 / 0.021 a
6.8 × 10–03 / 9.7 × 10–03 a
0.013 / 0.012 a
0.019 / 0.021 a
0.015 / 0.019 a
Golden Retriever(235) ss7212922155
ss7212922147
ss7212922135
CFA11: 54489194
CFA12: 16410934
CFA14: 56572744
[4]
[11]
[6]
G/A
A/G
T/C
0.57 [0.37–0.89]
0.56 [0.33–0.97]
1.55 [1.02–2.35]
0.014 / 0.013 b
0.037 / 0.033 b
0.040 / 0.034 b
Lagotto Romagnolo(194) ss7212922120
ss7212922155
ss7212922151
CFA1: 45382633
CFA11: 54489194
CFA26: 14157064
[13]
[4]
[7]
C/Ac
G/A
T/C
0.59 [0.36–0.95]
0.60 [0.38–0.94]
2.00 [1.08–3.71]
0.029 / 0.028 a
0.025 / 0.040 a
0.025 / 0.028 a
Samoyed(149) ss7212922144
ss7212922163
CFA3: 40302288
CFA24: 25973438
[11]
[7]
A/G
C/G
0.47 [0.28–0.78]
1.75 [1.06–2.90]
3.2 × 10–03 / 7.3 × 10–03 a
0.029 / 0.033 a
Spanish Water dog(114) ss7212922131
ss7212922122
CFA21: 40146141
CFA33: 7967486
[10]
[8]
C/T
C/T
0.51 [0.29–0.89]
0.48 [0.25–0.90]
0.017 / 0.014 b
0.023 / 0.022 b
Great Dane(113) ss7212922137
ss7212922133
CFA1: 46279297
CFA14: 20864104
[13]
[6]
G/A
C/G
2.14 [1.15–3.97]
5.07 [1.04–24.73]
0.016 / 0.017 b
0.045 / 0.036 b
Labrador Retriever(100) ss7212922118
ss7212922126
ss7212922153
ss7212922141
ss7212922163
ss7212922154
CFA1: 45161186
CFA1: 67883139
CFA1: 67942900
CFA11: 29908777
CFA24: 25973438
CFA34: 11240092
[13]
[9]
[9]
[4]
[7]
[8]
C/G
A/T
T/A
A/T
G/C
G/A
1.83 [1.01–3.29]
2.51 [1.09–5.74]
2.55 [1.11–5.86]
0.47 [0.25–0.87]
1.87 [1.07–3.28]
0.52 [0.27–0.97]
0.046 / 0.037 b
0.030 / 0.023 b
0.027 / 0.020 b
0.016 / 0.017 b
0.029 / 0.023 b
0.040 / 0.027 b
Karelian Bear dog(97) ss7212922161
ss7212922156
ss7212922152
ss7212922155
CFA1: 67876393
CFA8: 28489063
CFA8: 28489546
CFA11: 54489194
[12]
[12]
[12]
[4]
A/C
T/C
A/C
A/G
0.46 [0.23–0.91]
0.41 [0.17–0.96]
0.41 [0.17–0.96]
2.94 [1.41–6.10]
0.025 / 0.019 b
0.041 / 0.035 b
0.041 / 0.035 b
3.9 × 10–03 / 4.3 × 10–03 b
Finnish Hound (102) ss7212922123 CFA17: 45022358 [4] T/G 2.38 [1.31–4.34] 4.1 × 10–03 / 8.7 × 10–03 a
  1. aX2-test. bLogistic regression. CI confidence interval; OR odds ratio. The odds ratios and their confidence intervals were calculated by PLINK using default settings in which the minor allele increases the risk when OR > 1. The reference genome used in this study is CanFam3.1. cNo significant associations were observed in Bernese Mountain dogs. dMajor/minor allele designation of ss7212922120 is changed in Lagotto Romagnolo cohort