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Fig. 3 | BMC Genomics

Fig. 3

From: Phylogenetic analysis of the caspase family in bivalves: implications for programmed cell death, immune response and development

Fig. 3

a Phylogenetic relationship of executioner caspases in bivalves (blue) compared to other vertebrate and invertebrate homologues (black). Values above/below branches separated by slash show bootstrap support values for Maximum Likelihood (ML) analysis as percentage of bootstrap values for the main tree with additional Bayesian Inference (BI) posterior probabilities. /x indicates the nodes obtained from the BI which were different from the ML analysis. Human caspase-8 used as outgroup. b Schematic representation of caspase structure with two caspase specific domains: large p20 and small p10 domain. The p20 active sites motif (..H … ..QACXG) with the conserved histidine and cysteine residue in bold is shown for each bivalve caspase homolog. DSRM: double stranded RNA-binding motif. c Schematic representation of gene location for each identified C. gigas caspase on the pseudo-chromosomes (LG). Mb: megabase pairs. Aj: Apostichopus japonicus, Av: Anemonia viridis, Bl: Branchiostoma lanceolatum, Bf: Branchiostoma floridae, Ca: Crassostrea angulata, Cg: Crassostrea gigas, Ch: Crassostrea hongkongensis, Co: Cynops orientalis, Dm: Drosophila melanogaster, Dr.: Danio rerio, Ep: Exaiptasia pallida, Es: Eriocheir sinensis, Hd: Haliotis diversicolor, Hl: Holothuria leucospilota, Hs: Homo sapiens, Hv: Hydra vulgaris, Lm: Locusta migratoria, Meg: Meleagris gallopavo, Mg: Mytilus galloprovincialis, Mj: Marsupenaeus japonicas, Mm: Mus musculus, On: Oreochromis niloticu, Pm: Penaeus monodon, Pme: Penaeus merguiensis Sf: Spodoptera frugiperda, Sm: Schistosoma mansoni, Ss: Salmo salar, Tg: Tegillarca granosa, Xl: Xenopus laevis. _amf: amphibian, −amp: amphioxus, _art: arthropod, _bird: bird, _cni: cnidarian, _ech: echinoderm, _fish: fish, _mam: mammal, _mol: mollusc, _pla: plathelminth, _rep: reptile

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