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Fig. 5 | BMC Genomics

Fig. 5

From: A novel missense mutation in the gene encoding major intrinsic protein (MIP) in a Giant panda with unilateral cataract formation

Fig. 5

Predicted changes in the tertiary structure of giant panda MIP caused by the missense mutation p.S229N. a Changes in surface structure visualized using Discovery Studio Visualizer. The yellow circle reveals a subtle but distinct protrusion in the mutant protein caused by the bulkier side chain of asparagine compared to serine. b Interactions between amino acid side chains predicted using THREADER and Modeller. The p.S229N mutant forms two new hydrogen bonds

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