Table 3 Proteins associated to S. aureus Pathogenesis (GO: GO:0009405). Domains that are shared between S. aureus and S. pyogenes are underlined. Proteins that are shared have are written in bold

PF00746;PF07501; PF17041

LPXTG cell wall anchor; G5 domain, suggested adhesion, in peptide that cleaves IgA; E domain, rod like structure

PF00746; PF17210

LPXTG cell wall anchor, SdrD B-like domain, involved in adhesion to nose squamous cells [28]

PF13545

Crp-like helix-turn-helix domain, possibly cAMP interaction

PF05543

Staphopain peptidase C47, secreted cysteine protease

PF14731

Staphopain proregion

PF03373

Octapeptide repeat, part of SpA virulence factor frequently used to type S. aureus strains [29]

PF07968

Haemolysin, part of the Leukocidin/Hemolysin toxin family

PF09199

Staphylococcal superantigen-like OB-fold domain, interact with IgA, inhibits the end stage of complement activation and IgA binding to Fc-α-R [30]

PF02216

SpAB protein domain, immunoglobin binding domain

PF02876

Staphylococcal/Streptococcal toxin, beta-grasp domain

PF11621

C3 binding domain 4 of IgG-bind protein SB

PF01123

Enterotoxin type B, supertoxin, involved in food poisoning, causing the immune system to release a large number of cytokines that lead to significant inflammation

PF03642

MAP domain, major histocompatibility complex class II analog

PF00746;PF01476

LPXTG cell wall anchor motif; LysM domain found in many receptors, peptidoglycan-binding protein [12]

PF00746;PF02986

LPXTG cell wall anchor motif; Fibronectin binding repeat, enables uptake by host cell

PF00746;PF05031

LPXTG cell wall anchor motif; Iron Transport-associated domain, heme and/or hemoprotein-binding

PF07564

Domain of Unknown Function (DUF1542), several proteins containing this domain are involved in antibiotic resistance and/or cell adhesion

PF09023

Staphostatin B inhibits the cysteine protease Staphopain B

PF02821

Streptokinase (SK) is a thrombolytic medication and enzyme, breaks down blood cloths

PF01468

GA module, GA modules may promote bacterial growth and virulence in mammalian hosts by scavenging albumin-bound nutrients and camouflaging the bacteria

PF07554;PF07564;PF08428

FIVAR domain, likely binds fibronectin or more specifically N-acetyl glucosamine, occurs in proteins involved in methicillin resistance; Domain of Unknown Function (DUF1542); Rib/alpha-like repeat. Occurs in some Rib, a thought to confer protective immunity. Occurs in some Streptococcus surface proteins. Extracellular matrix-binding protein Ebh