Table 4 Results of enrichment by GO and KEGG analysis for the candidate genes
Trait | Term | P-value | Enrich Genes |
|---|---|---|---|
FD, FDCV and FDSD | integral component of endoplasmic reticulum membrane (GO:0030176) | 0.0000672 | SAMD8, FKBP8, EXT1, DCSTAMP |
positive regulation of monocyte chemotaxis (GO:0090026) | 0.02651675 | LOC101117971, TNFSF18 | |
presynaptic membrane (GO:0042734) | 0.030568552 | CADPS2, NRXN1 | |
positive regulation of inflammatory response (GO0050729) | 0.052361511 | TNFSF4, TNFSF18 | |
Cytokine-cytokine receptor interaction (oas04060) | 0.012537021 | LOC101103766, TNFSF4, LOC101117971, TNFSF18 | |
Glycosaminoglycan biosynthesis - heparan sulfate heparin (oas00534) | 0.053641685 | HS6ST3, EXT1 | |
SL and GFW | regulation of establishment of cell polarity (GO:2000114) | 0.05354365 | WDPCP, KANK1 |
negative regulation of insulin receptor signaling pathway (GO:0046627) | 0.057544264 | PID1, KANK1 | |
nucleotide binding (GO:0000166) | 0.074031682 | LARP6, ADCY1, EIF3B, EWSR1 | |
regulation of autophagy (GO:0010506) | 0.081203017 | ABL2, USP13 | |
Cell adhesion molecules (CAMs) (oas04514) | 0.009109937 | LOC101108158, CADM1, NLGN1, CNTNAP2 | |
Glutamatergic synapse (oas04724) | 0.031888822 | ADCY1, GRIA2, GRM7 | |
SS and SE | positive regulation of canonical Wnt signaling pathway (GO:0090263) | 0.010663274 | YAP1, LRRK1, SRC |
osteoclast development (GO:0036035) | 0.011584332 | LRRK1, SRC | |
extracellular-glutamate-gated ion channel activity (GO:0005234) | 0.039331749 | GRIN2A, GRID2 | |
bone resorption (GO:0045453) | 0.042775594 | LRRK1, SRC | |
excitatory postsynaptic potential (GO:0060079) | 0.051115614 | GRIN2A, GRID2 |