Fig. 2

Orthologous and paralogous relationship of CEACAM genes in primates. Phylogenetic trees were constructed based on IgV-like N domain exon nucleotide sequences of CEACAM genes from 57 primate species using the Maximum Likelihood method (MEGA6 software). The tree with the highest log likelihood is shown. The CEACAM1-like genes are marked in green, the PSG paralogs in red. CEACAM1, CEACAM3, CEACAM5 and CEACAM6 represent paralogs and, CEACAM4, CEACAM7, CEACAM8 and CEACAM21 exhibit an orthologous relationship. Note that CEACAM21 and PSG-like genes are only present in apes and NWM, respectively. The scale next to the dendrogram shows the number of substitutions per site. CEACAM, CEA-related cell-cell adhesion molecule; NWM, New World monkeys; OWM, Old World monkeys; Oga, Otolemur garnettii, bushbaby; PSG, pregnancy-specific glycoprotein; Tsy, Tarsius syrichta, tarsier