Fig. 5

Enriched canonical pathways. Red (−) dots represent canonical pathways of which genes were significantly lower expressed in the 4-cell versus morula and morula versus hatched blastocysts, and blue (+) represent canonical pathways of which genes were significantly higher expressed in the 4-cell versus morula or morula versus hatched blastocysts. The GeneRatio indicates the proportion of DEGs that were identified in an enriched canonical pathway. Shared enriched canonical pathways in both in vivo developed and in vitro produced embryos at the 4-cell versus morula or morula versus hatched blastocyst stage are indicated in purple