Fig. 5

MyD88 KO BMDM have similar gene expression signatures as wild type BMDM. BMDM from MyD88 KO mice were infected with either the RH or PTG strain, and 6 h later RNA was isolated for sequencing. Differentially expressed mouse transcripts were identified based on statistical significance (PPDE greater than 0.95) and a fold change of greater or less than 2. a Classification of differentially expressed MyD88 KO transcripts as either protein-coding, non-coding, pseudogene, or TEC (To be Experimentally Confirmed). b Total number of protein-coding transcripts of higher or lower abundance during infection. c Venn diagrams of differentially expressed protein-coding transcripts. d Classification of differentially expressed MyD88 KO non-coding transcripts by type. e Total number of non-coding transcripts of higher or lower abundance during infection. f Venn diagrams of regulated non-coding transcripts revealing shared and unique expression patterns between infection strains. Experiments were performed in at least triplicate with BMDM from separate mice