Skip to main content

Table 4 Summary of published data on genes that belong to the retinoic acid response protein interaction clusters

From: Multi-species transcriptome meta-analysis of the response to retinoic acid in vertebrates and comparative analysis of the effects of retinol and retinoic acid on gene expression in LMH cells

Gene Protein Cluster Published data on RA-response
ADRA2C Alpha-2C adrenergic receptor i Putative RXRβ and RARα binding motifs in the regulatory region [15]
CCDC80 Coiled-coil domain-containing protein 80 i Upregulation in BM cells [16]
CCL19 C-C motif chemokine 19 i Has been linked indirectly in numerous studies
CNR1 Cannabinoid receptor 1 i Increase in hepatic expression [17]
GDNF Glial cell line-derived neurotrophic factor i Downregulation in embryonic chicken sympathetic neurons [18]
IL18 Interleukin-18 i Pathogen clearance in the gut via IL-18 [19]
NTRK2 BDNF/NT-3 growth factors receptor i Linked to RA-induced neuroblastoma differentiation [20]
OXT Oxytocin-neurophysin 1 i Responds to RA via retinoic acid response element in the OXT promoter region [21]
P2RX1 P2X purinoceptor 1 i /
RET Proto-oncogene tyrosine-protein kinase receptor Ret i Induction of neurite extension [22]
SEMA3A Semaphorin-3A i Upregulation in SH-SY5Y cells [23]
TACR3 Neuromedin-K receptor i /
CYP26A1 Cytochrome P450 26A1 ii RA hydroxylase [24]
CYP26B1 Cytochrome P450 26B1 ii
CYP26C1 Cytochrome P450 26C1 ii
DHRS3 Short-chain dehydrogenase/reductase 3 ii reduces all-trans-retinal or oxidizes all-trans-retinol [25]
HIC1 Hypermethylated in cancer 1 protein ii /
HOXA2 Homeobox protein Hox-A2 ii Hox gene expression activated by RA (reviewed in (20))
HOXB1 Homeobox protein Hox-B1 ii
HOXB2 Homeobox protein Hox-B2 ii
RARB Retinoic acid receptor beta ii RA receptor [26]
CLDN11 Claudin-11 iii Upregulation in glioma stem-like cells [27]
CLDN2 Claudin-2 iii Upregulation in keratinocytes [28]
ERMN Ermin iii /
GALNT5 Polypeptide N-acetylgalactosaminyltransferase 5 iii /
IFNW1 Interferon omega-1 iii /
TSPAN10 Tetraspanin-10 iii /