Table 4 Summary of published data on genes that belong to the retinoic acid response protein interaction clusters

ADRA2C

Alpha-2C adrenergic receptor

i

Putative RXRβ and RARα binding motifs in the regulatory region [15]

CCDC80

Coiled-coil domain-containing protein 80

i

Upregulation in BM cells [16]

CCL19

C-C motif chemokine 19

i

Has been linked indirectly in numerous studies

CNR1

Cannabinoid receptor 1

i

Increase in hepatic expression [17]

GDNF

Glial cell line-derived neurotrophic factor

i

Downregulation in embryonic chicken sympathetic neurons [18]

IL18

Interleukin-18

i

Pathogen clearance in the gut via IL-18 [19]

NTRK2

BDNF/NT-3 growth factors receptor

i

Linked to RA-induced neuroblastoma differentiation [20]

OXT

Oxytocin-neurophysin 1

i

Responds to RA via retinoic acid response element in the OXT promoter region [21]

P2RX1

P2X purinoceptor 1

i

/

RET

Proto-oncogene tyrosine-protein kinase receptor Ret

i

Induction of neurite extension [22]

SEMA3A

Semaphorin-3A

i

Upregulation in SH-SY5Y cells [23]

TACR3

Neuromedin-K receptor

i

/

CYP26A1

Cytochrome P450 26A1

ii

RA hydroxylase [24]

CYP26B1

Cytochrome P450 26B1

ii

“

CYP26C1

Cytochrome P450 26C1

ii

“

DHRS3

Short-chain dehydrogenase/reductase 3

ii

reduces all-trans-retinal or oxidizes all-trans-retinol [25]

HIC1

Hypermethylated in cancer 1 protein

ii

/

HOXA2

Homeobox protein Hox-A2

ii

Hox gene expression activated by RA (reviewed in (20))

HOXB1

Homeobox protein Hox-B1

ii

“

HOXB2

Homeobox protein Hox-B2

ii

“

RARB

Retinoic acid receptor beta

ii

RA receptor [26]

CLDN11

Claudin-11

iii

Upregulation in glioma stem-like cells [27]

CLDN2

Claudin-2

iii

Upregulation in keratinocytes [28]

ERMN

Ermin

iii

/

GALNT5

Polypeptide N-acetylgalactosaminyltransferase 5

iii

/

IFNW1

Interferon omega-1

iii

/

TSPAN10

Tetraspanin-10

iii

/