Gene Symbola | Gene Namea | Functional Themeb | Key Function (UniProt)c | FC WNd | FC WHe |
---|---|---|---|---|---|
Genes Related to Heat Shock Response | |||||
 hsp70 | Heat shock protein HSP 70 | Heat Shock Response (#1) | MF: Chaperone, Receptor; BP: Stress response | 2.0 ± 0.37 | 2.0 ± 0.38 |
 hsp90aa1 | Heat shock protein HSP 90-alpha | Heat Shock Response (#1) | MF: Chaperone; BP: Stress response | 3.1 ± 0.31 | 3.7 ± 0.67 |
 hsp90ab1 | Heat shock protein HSP 90-beta | Heat Shock Response (#1) | MF: Chaperone; BP: Stress response | 1.3 ± 0.19 | 1.4 ± 0.22 |
 hspd1 | 60 kDa heat shock protein | Heat Shock Response (#1) | MF: Chaperone, Isomerase; BP: Stress response | 0.3 ± 0.02 | 0.4 ± 0.04 |
 serpinh1 (hsp47) | Serpin H1 | Heat Shock Response (#1) | MF: Chaperone; BP: Stress response, Collagen biosynthesis | 5.5 ± 0.89 | 6.3 ± 0.78 |
Genes Related to Stress Response | |||||
 calm (cam) | Calmodulin | Cellular Stress (#2), Oxidative Stress (#3) | MF: Calcium ion binding; BP: Calcium-mediated signaling | 0.4 ± 0.06 | 0.4 ± 0.04 |
 cat | Catalase | Cellular Stress (#2), Oxidative Stress (#3) Apoptosis (#4) | MF: Oxidoreductase, Peroxidase; BP: Hydrogen peroxide | 1 ± 0.14 | 1 ± 0.11 |
 cirbp | Cold-inducible RNA-binding protein | Heat Shock Response (#1) Cellular Stress (#2), Oxidative Stress (#3) | MF: Activator, Repressor, RNA-binding; BP: Stress response | 0.4 ± 0.03 | 0.3 ± 0.03 |
 cldn3 | Claudin 3 | Cellular Stress (#2), | MF: Transmembrane signaling; BP: Tight junction, Protein binding | 0.8 ± 0.07 | 1 ± 0.1 |
 cul3 | Cullin 3 | Cellular Stress (#2), Apoptosis (#4) | MF: Protein ubiquitination; BP: ER-Golgi transport, Transport | 1.2 ± 0.08 | 1 ± 0.06 |
 cyp1a1 | Cytochrome P450 1A1 | Cellular Stress (#2), Oxidative Stress (#3) | MF: Oxidoreductase; BP: Oxidation-reduction process | 0.2 ± 0.05 | 0.2 ± 0.04 |
 egln2 (phd1) | Egl nine homolog 2 | Cellular Stress (#2), Oxidative Stress (#3), Apoptosis (#4) | MF: Oxidoreductase, Oxygen sensor activity; BP: Cell redox homeostasis, Response to hypoxia | 0.4 ± 0.03 | 0.4 ± 0.05 |
 gstt1 | Glutathione S-transferase theta-1 | Cellular Stress (#2), Oxidative Stress (#3) | MF: Transferase; BP: Glutathione metabolic process | 0.6 ± 0.09 | 0.5 ± 0.09 |
 hcn1 | Hyperpolarization-activated cyclic nucleotide-gated channel 1 | Cellular Stress (#2), Oxidative Stress (#3) | MF: Ion channel; BP: Ion transport, Transport | 5.4 ± 1.27 | 5.7 ± 1.06 |
 hif1α | Hypoxia-inducible factor 1 alpha | Cellular Stress (#2), Oxidative Stress (#3), Immune (#5) | MF: DNA-binding; Oxygen sensor activity; BP: Transcription regulation, Response to hypoxia | 0.60 ± 0.06 | 0.57 ± 0.06 |
 igfbp2b1 | Insulin-like growth factor-binding protein 2 - paralog b1 | Oxidative Stress (#3) | MF: Growth factor binding; BP: Growth regulation | 0.6 ± 0.14 | 0.6 ± 0.15 |
 jak2 | Tyrosine-protein kinase JAK2-like | Cellular Stress (#2), Oxidative Stress (#3), Apoptosis (#4), Immune (#5) | MF: Chromatin regulator, Tyrosine-protein kinase; BP: Apoptosis, Immunity | 1.7 ± 0.22 | 1.5 ± 0.16 |
 jund | Transcription factor Jun-D-like | Cellular Stress (#2), Apoptosis (#4), Immune (#5) | MF: Activator, DNA-binding; BP: Transcription, Transcription regulation | 3.2 ± 0.53 | 3 ± 0.35 |
 ndufa1 | NADH dehydrogenase 1 alpha subcomplex subunit 1 | Cellular Stress (#2), Oxidative Stress (#3) | MF: NADH dehydrogenase; BP: Electron transport, Respiratory chain | 1 ± 0.05 | 1 ± 0.02 |
 ndufa4 | Cytochrome c oxidase subunit NDUFA4 | Cellular Stress (#2), Oxidative Stress (#3) | MF: NADH dehydrogenase; BP: Electron transport, Respiratory chain | 2.2 ± 0.43 | 1.3 ± 0.45 |
 prdx6 | Peroxiredoxin 6 | Cellular Stress (#2), Oxidative Stress (#3) | MF: Antioxidant, Peroxidase; BP: Cellular response to oxidative stress | 0.4 ± 0.01 | 0.4 ± 0.02 |
 rraga | Ras-related GTP-binding protein A | Cellular Stress (#2), Oxidative Stress (#3), Apoptosis (#4) | MF: GTP-binding, Hydrolase; BP: Apoptosis | 0.5 ± 0.04 | 0.5 ± 0.03 |
 txn | Thioredoxin | Cellular Stress (#2), Oxidative Stress (#3) Apoptosis (#4) | MF: Activator; BP: Oxidation-reduction process | 1.9 ± 0.37 | 1.5 ± 0.26 |
 ucp2 | Mitochondrial uncoupling protein 2 | Cellular Stress (#2), Oxidative Stress (#3), Apoptosis (#4) | MF: Oxidative phosphorylation; BP: Transport | 0.2 ± 0.04 | 0.2 ± 0.03 |
Genes Related to Immune Response | |||||
 apod | Apolipoprotein D-like | Immune (#5), Apoptosis (#4), Oxidative Stress (#3) | MF: Lipid-binding, Lipid transport; BP: Transport, Immunity | 4.4 ± 2.73 | 7.7 ± 2.55 |
 c1ql2 | Complement C1q-like protein 2 | Immune (#5), Apoptosis (#4) | MF: Protein binding; BP: Defence response to bacterium | 6.4 ± 0.78 | 12.3 ± 4.47 |
 c3 | Complement C3-like | Immune (#5) | MF: Signaling receptor binding; BP: Complement alternate pathway, Inflammatory response, Innate immunity | 0.6 ± 0.11 | 0.6 ± 0.12 |
 camp-a | Cathelicidin - paralog a | Immune (#5) | MF: Antimicrobial peptide; BP: Bacterial defence | 0.9 ± 0.2 | 3 ± 0.89 |
 casp8 | Caspase 8 | Immune (#5), Apoptosis (#4) | MF: Hydrolase, Protease, Thiol-protease; BP: Apoptosis, Host-virus interaction | 1.7 ± 0.12 | 1.6 ± 0.11 |
 ctsh | Cathepsin H precursor | Immune (#5), Apoptosis (#4) | MF: Hydrolase, Protease, Thiol-protease; BP: Proteolysis | 0.3 ± 0.03 | 0.3 ± 0.03 |
 epx | Eosinophil peroxidase-like | Immune (#5), Oxidative Stress (#3) | MF: Oxidoreductase, Peroxidase; BP: Bacterial defence, Oxidative stress response | 3.1 ± 0.85 | 2.3 ± 0.57 |
 il8 (cxcl8) | Interleukin 8 (Chemokine CXC) | Immune (#5) | MF: Cytokine; BP: Chemotaxis, Inflammatory response | 1.4 ± 0.33 | 2.6 ± 0.73 |
 irf2 | Interferon regulatory factor 2 | Immune (#5) | MF: Activator, DNA-binding, Repressor; BP: Transcription regulation | 0.8 ± 0.15 | 0.8 ± 0.17 |
 mhcii (hla-dra) | MHC class ii antigen alpha chain | Immune (#5) | MF: Peptide antigen binding; BP: Adaptive immunity, Immunity | 1 ± 0.16 | 1.5 ± 0.32 |
 mmp9 | Matrix metalloproteinase 9 | Immune (#5), Apoptosis (#4) | MF: Hydrolase, Metalloprotease, BP: Collagen degradation | 2 ± 0.54 | 1.4 ± 0.25 |
 nckap1l | Nck-associated protein 1-like | Immune (#5), Apoptosis (#4) | MF: Protein kinase activator; BP: Apoptosis | 0.6 ± 0.05 | 0.6 ± 0.04 |
 tapbp | Tapasin | Immune (#5) | MF: Peptide antigen binding; BP: Immune response, Antigen presentation | 0.8 ± 0.17 | 0.9 ± 0.21 |
 tnfrsf6b | Tumor necrosis factor receptor superfamily member 6b | Immune (#5), Apoptosis (#4) | MF: Signaling Receptor; BP: Apoptosis | 1.6 ± 0.45 | 2.8 ± 0.71 |
Genes Related to Cellular Metabolism | |||||
 gck | Glucokinase | Cellular Metabolic Processes (#10) | MF: Allosteric enzyme, Kinase, Transferase; BP: Glycolysis | 0.5 ± 0.25 | 0.7 ± 0.35 |
 pdk3 | Pyruvate dehydrogenase [lipoamide] kinase isozyme 3 | Cellular Metabolic Processes (#10) | MF: Kinase, Transferase; BP: Carbohydrate metabolism, Glucose metabolism | 1.8 ± 0.15 | 1.3 ± 0.11 |
Gene Related to Transcriptional Regulation | |||||
 dnmt1 | DNA (cytosine-5)-methyltransferase 1 | Transcription (#7) | MF: Chromatin regulator, DNA-binding, Methyltransferase; BP: DNA methylation | 0.5 ± 0.02 | 0.5 ± 0.04 |