Table 4 Top 15 pathways significantly enriched by genes associated with SNPs significant (−log[p-value] ≥3) in GWAS a performed using the merged dataset of genotypes (DNA and RNA-seq)
Pathways | Reactome term | p-value |
|---|---|---|
Metabolism of water-soluble vitamins and cofactors | R-BTA-196849 | 0.0002 |
Endogenous sterols | R-BTA-211976 | 0.0005 |
Metabolism of vitamins and cofactors | R-BTA-196854 | 0.0019 |
Regulation of pyruvate dehydrogenase (PDH) complex | R-BTA-204174 | 0.0024 |
Metabolism | R-BTA-1430728 | 0.0047 |
Nicotinate metabolism | R-BTA-196807 | 0.0051 |
Pyruvate metabolism and Citric Acid (TCA) cycle | R-BTA-71406 | 0.0060 |
Signaling by Retinoic Acid | R-BTA-5362517 | 0.0074 |
Pyruvate metabolism | R-BTA-70268 | 0.0085 |
Biotin transport and metabolism | R-BTA-196780 | 0.0088 |
Energy dependent regulation of mTOR by LKB1-AMPK | R-BTA-380972 | 0.0107 |
Metabolism of lipids | R-BTA-556833 | 0.0110 |
Gap-filling DNA repair synthesis and ligation in TC-NER | R-BTA-6782210 | 0.0120 |
Cytochrome P450 - arranged by substrate type | R-BTA-211897 | 0.0124 |
GRB2:SOS provides linkage to MAPK signaling for Integrins | R-BTA-354194 | 0.0136 |