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Fig. 1 | BMC Genomics

Fig. 1

From: Strain-based and sex-biased differences in adrenal and pancreatic gene expression between KK/HlJ and C57BL/6 J mice

Fig. 1

a 4-way Venn diagram analysis shows numbers of significant pancreatic differentially expressed genes (DEGs) and their overlapping categorization using multiple comparisons with fold-changes (FC≥± 1.4, FDR < 0.05) for Set 1: male KK/HlJ versus male C57BL/6 J (KK-M vs. C57-M, yellow); Set 2: male KK/HlJ versus female KK/HlJ (KK-M vs. KK-F, red), Set 3: female KK/HlJ versus female C57BL/6 J (KK-F vs. C57-F, green), and Set 4: male C57BL/6 J versus female C57BL/6 J (C57-M vs. C57-F, blue). b Heatmap with hierarchical clustering of differentially expressed pancreatic genes (FDR < 0.05) between the 4 Sets. Z-scores denote the relative gene expression levels with red and green representing high and low expression, respectively. c 2-way Venn diagram analysis of numbers of strain-biased pancreatic DEGs identified from the comparisons of Set 1 (KK-M vs. C57-M: yellow) and Set 3 (KK-F vs. C57-F: green), (FC≥± 1.4, FDR < 0.05). Green arrows represent up-regulated in KK-HlJ compared to C57BL/6 J, and red arrows represent down-regulated. d 2-way Venn diagram analysis of numbers of sex-biased pancreatic DEGs identified from the comparisons of Set 2 (KK-M vs. KK-F: blue) and Set 4 (C57-M vs. C57-F: red), (FC≥± 1.4, FDR < 0.05)

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