KK-M | KK-F | C57-M | C57-F | p-value strain*sex | |
---|---|---|---|---|---|
Body weight (g) | 37.11** ± 0.58 | 36.99** ± 1.04 | 28.79$$ ± 0.35 | 21.34 ±0.21 | < 0.001 |
Visceral fat weight (g) | 1.20** ± 0.03 | 3.78$$** ± 0.23 | 0.63$$ ± 0.04 | 0.27 ± 0.02 | < 0.001 |
Pancreas weight (g) | 0.33* ±0.01 | 0.35* ± 0.05 | 0.30$$ ± 0.01 | 0.22 ± 0.01 | 0.100 |
Insulin Tolerance Test (ITT) | |||||
Basal Glucose (mg/dL) | 251.33$$$** ± 18.93 | 165.77** ± 5.50 | 136.14 ± 4.28 | 130.83 ± 3.52 | < 0.001 |
AUCGLUCOSE (mg/dL.min) | 13,145.2$$$** ± 703.18 | 8790.41** ± 371.24 | 7404.58$$ ± 214.05 | 6346.80 ± 299.54 | < 0.001 |
KITT (%/min) | 1.01 ± 0.11 | 1.07 ± 0.16 | 0.84 ± 0.07 | 1.22$$ ± 0.13 | 0.099 |
T1/2GLUCOSE (min) | 69.21 ± 8.24 | 69.65 ± 7.89 | 68.18$ ± 3.32 | 57.51 ± 6.31 | 0.720 |
Fasting Blood measurements | |||||
Serum Glucose (mg/dL) | 144.61 ± 5.28 | 144.42** ± 4.61 | 138.86$$$ ± 3.67 | 119.67 ± 2.52 | 0.024 |
Serum Insulin (uIU/mL) | 46.92** ± 4.71 | 32.16** ± 5.55 | 9.72 ± 0.54 | 8.51 ± 0.77 | 0.061 |
HOMA-IR | 16.30** ± 1.44 | 11.31** ± 1.90 | 3.32$ ± 0.19 | 2.50 ± 0.23 | 0.076 |
C-Peptide | 2134.30$$$** ± 281.96 | 975.47* ± 119.45 | 822.35$ ± 91.05 | 543.42 ± 96.07 | 0.007 |
Glucagon (pg/ml) | 29.02 ± 4.43 | 157.65*$$$ ± 16.63 | 35.15 ± 4.66 | 96.93$$$ ± 9.73 | < 0.001 |
Leptin | 6360.02** ± 305.11 | 6070.94** ± 454.04 | 2439.69$$ ± 248.33 | 1291.04 ± 221.96 | 0.184 |
Corticosterone (ng/ml) | 103.36 ± 10.40 | 200.74$$$ ± 21.42 | 92.32 ± 9.56 | 160.67$$ ± 17.86 | 0.351 |
Aldosterone (pg/ml) | 649.63*** ± 50.60 | 571.13*** ± 45.26 | 329.75 ± 33.96 | 348.54 ± 31.15 | < 0.0001 |
IL-6 (pg/ml) | 62.02 ± 13.20 | 82.44* ± 16.22 | 39.72 ± 4.64 | 31.08 ± 5.43 | 0.179 |
TNF-α (pg/ml) | 8.07* ± 0.96 | 9.25 ± 0.81 | 13.83$ ± 1.11 | 9.25 ± 1.56 | 0.015 |